Hyaluronic Acid Transdermal Patch for Cannabinoid Delivery

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Solution Overview

Problem

Current methods for delivering cannabinoids, such as cannabidiol (CBD), face challenges due to their hydrophobic nature, which limits absorption through the skin and requires significant surface area and time for effective transdermal administration, and existing delivery systems often result in delayed absorption and variable efficacy for pain relief and cancer treatment.

Innovation Solution

The development of transdermal patches and injectable needles/cannulas made from hyaluronic acid (HA), which expand upon contact with liquid to create a delivery pathway, allowing for controlled release of CBD and other cannabinoids, enhancing skin penetration and absorption, and the use of HA to bind with cannabinoids for targeted delivery to cancerous cells.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If transdermal patches are used to deliver cannabinoids, then the medication can be administered through the skin, but the hydrophobic nature of cannabinoids limits absorption and requires significant surface area and time for effective delivery

Engineering Contradiction:

Improvetransdermal administrationVSAvoidabsorption efficiency

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The patent introduces hyaluronic acid as an intermediary substance that facilitates the transfer of hydrophobic cannabinoids through the skin barrier. The HA acts as a mediator between the hydrophobic drug and the hydrophilic skin environment, enabling effective transdermal delivery without requiring large surface areas or extended time periods.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention creates a composite delivery system combining hyaluronic acid with cannabinoids to form a hybrid material that possesses both the skin-penetrating capabilities of HA and the therapeutic properties of cannabinoids. This composite approach overcomes the inherent limitation of cannabinoid hydrophobicity while maintaining ease of transdermal application.

Inventive Principle:

Principle #40Composite materials

2Ease of manufacture

If existing delivery systems are used, then medication can be administered, but absorption is delayed and efficacy is variable for pain relief and cancer treatment

Engineering Contradiction:

Improvedelivery system implementationVSAvoidabsorption timing and efficacy consistency

Core Design Contradiction:

Ease of manufactureVSManufacturing precision

Solution Approach 1:

The patent modifies the physical and chemical parameters of the delivery system by using hyaluronic acid to change the dissolution rate and release profile of cannabinoids. This allows for controlled and consistent absorption timing, eliminating the variability seen in existing delivery systems while maintaining ease of implementation.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention prepares the cannabinoid-HA complex in advance with predetermined dissolution characteristics, so that upon application or administration, the medication releases at a consistent and predictable rate. This preliminary preparation ensures efficacy consistency without complicating the actual delivery process.

Inventive Principle:

Principle #10Preliminary action

3Measurement precision

If hyaluronic acid is used to bind with cannabinoids, then targeted delivery to cancerous cells is achieved, but the system must ensure controlled release and steady medication levels

Engineering Contradiction:

Improvetargeted delivery accuracyVSAvoidmedication release timing

Core Design Contradiction:

Measurement precisionVSDuration of action of moving object

Solution Approach 1:

The patent creates a dynamic release system where the hyaluronic acid-cannabinoid complex adjusts its release rate based on environmental conditions such as pH and enzymatic activity in different body tissues. This dynamic behavior enables both targeted delivery to cancerous cells and controlled sustained release, maintaining steady medication levels without requiring precise temporal control.

Inventive Principle:

Principle #15Dynamics

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach provides efficient, long-lasting, and near-instantaneous delivery of cannabinoids, improving pain management and cancer treatment efficacy by ensuring steady medication levels and targeted drug release, while being suitable for various applications including pain relief, skincare, and cosmetic use.

Implementation Method 1

the injectable needles/cannulas are 3D printed hyaluronic acid structures that are hard structures prior to use and when in use, the hyaluronic acid expands upon contact with liquid and create a delivery pathway

Methodology Applied

Scientific EffectHydrogel expansion: Hydrogel