Hyaluronic Acid Transdermal Patch for Cannabis Delivery
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Solution Overview
Problem
Current methods for delivering cannabinoids, such as CBD and THC, face challenges due to their hydrophobic nature, leading to poor absorption and delayed effects, especially in transdermal patches, and existing delivery systems are not efficient for pain management and cancer treatment.
Innovation Solution
The development of transdermal patches and injectable systems using 3D printed hyaluronic acid structures and cannabis-infused oil, which expands to create delivery pathways, and the use of hyaluronic acid to bind cannabinoids for enhanced skin penetration and slow release, along with cannabis-infused oils for various applications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If transdermal patches use traditional hydrophobic cannabinoid delivery, then the patch structure is simple, but absorption is poor and effects are delayed
Solution Approach 1:
The patent combines hyaluronic acid (hydrophilic polymer) with cannabinoids (hydrophobic compounds) to create a composite delivery system. The hyaluronic acid matrix provides hydrophilic pathways that enhance the penetration and absorption of hydrophobic cannabinoids through the skin, resolving the contradiction between simple structure and effective absorption.
Solution Approach 2:
The patent changes the physical state of hyaluronic acid from solid to expanded gel state upon contact with skin moisture. This phase transition creates a hydrophilic environment that facilitates rapid cannabinoid absorption, reducing onset time while maintaining reliable delivery.
2Duration of action of moving object
If hyaluronic acid is used to bind cannabinoids for slow release, then duration of action is improved, but manufacturing complexity increases
Solution Approach 1:
The patent utilizes the natural self-cross-linking capability of hyaluronic acid through disulfide bond formation. The material automatically forms a cross-linked gel structure upon exposure to oxygen and moisture in the skin environment, eliminating the need for complex external cross-linking processes while achieving controlled slow release of cannabinoids.
Solution Approach 2:
The patent exploits the phase transition of hyaluronic acid from soluble to gel state through oxidative cross-linking. This natural gelation process creates a controlled release matrix that extends medication duration without requiring complex manufacturing steps, as the cross-linking occurs automatically during application.
3Reliability
If 3D printed hyaluronic acid needles are used for injection, then delivery pathway creation is improved, but device complexity increases
Solution Approach 1:
The patent designs the hyaluronic acid needles to undergo a parameter change from solid/rigid state during storage to expanded/gel state upon contact with liquid or tissue moisture. This transformation allows the needles to reliably create delivery pathways through tissue while the expansion process simplifies the overall device structure, as the complexity is inherent in the material's responsive behavior rather than mechanical components.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables efficient, long-lasting, and near-instant cannabis delivery, improving pain management and cancer treatment by enhancing absorption and bioavailability, and allowing for versatile applications in cosmetics and food products.
Implementation Method 1
the hyaluronic acid expands upon contact with liquid and create a delivery pathway
Implementation Method 2
Cannabinoid are hydrophobic while HA is hydrophilic so the HA can bind to body better than cannabis alone
Implementation Method 3
The HA is cross-linked to provide predetermined dissolution to release the medication in different layers of HA for release over time
Data Source
AI summary
A method for delivering therapeutics includes infusing a hydrogel with cannabis; and contacting the hydrogel infused with cannabis into a human which causes the controlled timed releasing of the cannabis with hydrophobic molecules to permeate through a lipid pathway.