Hyaluronic Acid Chewable Composition for Paralytic Ileus

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Solution Overview

Problem

Current treatments for postoperative paralytic ileus, such as mechanical bowel preparation, nasogastric feeding tubes, and gum chewing, are either ineffective or have adverse effects, failing to significantly reduce hospital stay times and complications.

Innovation Solution

A chewable composition containing hyaluronic acid and/or its salts, which stimulates salivation and peristalsis by hydrating the buccal mucous membrane, reducing post-anesthesia mouth dryness and promoting intestinal recovery.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If mechanical bowel preparation is used, then intestinal function recovery is improved, but patient discomfort and treatment complexity increase

Engineering Contradiction:

Improveintestinal function recoveryVSAvoidtreatment complexity

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The patent extracts the essential therapeutic component (hyaluronic acid) from complex mechanical bowel preparation procedures, delivering it through a simple chewable composition that can be easily administered without invasive equipment or complex protocols

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent replaces mechanical bowel preparation methods with a chemical/biological approach using hyaluronic acid, which stimulates intestinal peristalsis through pharmacological action rather than mechanical manipulation, thereby reducing treatment complexity while maintaining efficacy

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Quantity of substance

If nasogastric feeding tubes are used, then nutritional support is improved, but patient discomfort and risk of complications increase

Engineering Contradiction:

Improvenutritional supportVSAvoidpatient discomfort and complications

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent removes the need for nasogastric feeding tubes by extracting and delivering the key therapeutic agent (hyaluronic acid) through a non-invasive chewable formulation, eliminating tube-related discomfort and complications while maintaining nutritional support capability

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent uses hyaluronic acid as an intermediary substance that mediates between the need for intestinal stimulation and the avoidance of invasive tube placement, providing therapeutic effect without the harmful effects of nasogastric intubation

Inventive Principle:

Principle #24Intermediary (Mediator)

3Speed

If gum chewing is used, then intestinal motility is improved, but effectiveness in reducing hospital stay is limited

Engineering Contradiction:

Improveintestinal motilityVSAvoideffectiveness in reducing hospital stay

Core Design Contradiction:

SpeedVSReliability

Solution Approach 1:

The patent changes the parameters of gum chewing by incorporating hyaluronic acid at specific concentrations (0.01-0.7%), transforming it from a simple mechanical chewing exercise into a pharmacologically active treatment that more reliably accelerates intestinal motility and reduces hospital stay

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite chewing gum formulation combining traditional gum base with hyaluronic acid and other functional ingredients, producing a material that simultaneously provides mechanical chewing stimulation and pharmacological intestinal stimulation for enhanced effectiveness

Inventive Principle:

Principle #40Composite materials

4Productivity

If conventional treatments are used, then intestinal function is addressed, but treatment safety and patient tolerance are reduced

Engineering Contradiction:

Improveintestinal functionVSAvoidtreatment safety and tolerance

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The patent employs a disposable chewable composition that is safe, non-invasive, and easily eliminated, avoiding the safety risks and tolerance issues associated with invasive conventional treatments while effectively addressing intestinal function

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent changes the safety and tolerance parameters by using hyaluronic acid, a biocompatible and biodegradable substance with known safety profile, transforming the treatment from potentially harmful invasive procedures to a safe and well-tolerated oral formulation

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively reduces the time to resume intestinal function and hospital stay, is well-tolerated, and offers a safe, non-invasive treatment for postoperative paralytic ileus, with preliminary data showing improved outcomes compared to standard treatments.

Implementation Method 1

which stimulates salivation and peristalsis by hydrating the buccal mucous membrane

Methodology Applied

Scientific EffectHydration: Absorption (physical)

Implementation Method 2

Hyaluronic acid is one of the most hygroscopic molecules present in nature. The most important property of hyaluronic acid is therefore that of binding water

Methodology Applied

Scientific EffectHygroscopic property: Absorption (physical)

Data Source

PatentEP3107531B1New chewable composition

Publication Date: 2018.01.03 IDI INTEGRATORI DIETETICI ITALIANI SRL

AI summary

The present invention relates to a new chewable solid or semisolid composition comprising hyaluronic acid and/or salts thereof, and its use in the treatment and/or prevention of paralytic ileus.