Hyaluronic Acid Chlorhexidine Complex for Skin Irritation

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Solution Overview

Problem

Current chlorhexidine antimicrobial agents face issues such as poor water solubility, instability, and skin irritation, limiting their application range and effectiveness.

Innovation Solution

A water-soluble chlorhexidine derivative, hyaluronic acid chlorhexidine, is prepared through a complexation reaction between hyaluronic acid and chlorhexidine, enhancing solubility and stability, and eliminating skin irritation, allowing for the creation of antimicrobial solutions and gels with improved biocompatibility.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If chlorhexidine acetate is used as an antimicrobial agent, then broad-spectrum antimicrobial performance is achieved, but water solubility is poor and skin irritation occurs

Engineering Contradiction:

Improveantimicrobial performanceVSAvoidskin irritation

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent combines chlorhexidine with hyaluronic acid to create a composite material (hyaluronic acid chlorhexidine complex). This composite maintains the antimicrobial properties of chlorhexidine while incorporating the biocompatible, skin-friendly characteristics of hyaluronic acid, thereby resolving the contradiction between antimicrobial effectiveness and skin irritation.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent changes the chemical form of chlorhexidine from acetate or gluconate salts to a hyaluronic acid complex. This parameter change in the molecular structure and solubility characteristics improves water solubility and reduces skin irritation while preserving antimicrobial activity.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If chlorhexidine gluconate is used as an antimicrobial agent, then antimicrobial activity is maintained, but stability deteriorates under illumination

Engineering Contradiction:

Improveantimicrobial activityVSAvoidstability under illumination

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The hyaluronic acid-chlorhexidine composite structure provides photoprotection to the chlorhexidine molecule. The hyaluronic acid component acts as a stabilizing matrix that protects the chlorhexidine from light-induced decomposition, thereby improving stability under illumination while maintaining antimicrobial activity.

Inventive Principle:

Principle #40Composite materials

3Reliability

If chlorhexidine alcohol is used to improve antimicrobial effect, then killing effect on bacteria is enhanced, but water solubility decreases and skin damage increases

Engineering Contradiction:

Improvekilling effect on bacteriaVSAvoidskin damage

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent creates a composite where chlorhexidine is bound to hyaluronic acid, eliminating the need for alcohol as a co-solvent. The hyaluronic acid component provides skin compatibility and moisture retention, while the chlorhexidine maintains its bactericidal activity, thus achieving effective antimicrobial action without skin damage.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

Hyaluronic acid acts as an intermediary substance that bridges the gap between chlorhexidine's antimicrobial function and skin compatibility. It mediates the interaction between the antimicrobial agent and skin tissue, reducing direct contact between chlorhexidine and skin while maintaining therapeutic effectiveness.

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The hyaluronic acid chlorhexidine exhibits excellent broad-spectrum antimicrobial performance, improved water solubility, and biocompatibility, with no cytotoxicity, and can be used in various applications including medical devices, skin wound care, and environmental disinfection, demonstrating superior antibacterial efficacy compared to existing chlorhexidine products.

Implementation Method 1

The hyaluronic acid chlorhexidine is composed of hyaluronic acid and chlorhexidine in a form of a salt, which is prepared by a complexation reaction of hyaluronic acid and chlorhexidine

Methodology Applied

Scientific EffectComplexation reaction: Chemical Bonding

Data Source

PatentUS12256737B2Preparation method and application of water-soluble chlorhexidine hyaluronate antibacterial agents

Publication Date: 2025.03.25 SHANDONG AWA BIOPHARM

AI summary

Disclosed are a water-soluble chlorhexidine antimicrobial agent and a preparation method therefor and use thereof. The present disclosure takes hyaluronic acid as a raw material to prepare a hyaluronic acid aqueous solution or organic solution, then the hyaluronic acid aqueous solution or organic solution and a chlorhexidine solution are subjected to a complexation reaction, an insoluble substance therein is removed, and then the resulting solution is dried to obtain the water-soluble chlorhexidine antimicrobial agent, namely hyaluronic acid chlorhexidine. The hyaluronic acid chlorhexidine has a good broad-spectrum antimicrobial performance, and excellent water solubility. The hyaluronic acid chlorhexidine combines advantages of hyaluronic acid and chlorhexidine, has good biocompatibility, no cytotoxicity, no skin irritation, and good moisture retention, can be prepared into an antimicrobial aqueous solution or gel, ointment and other products, and is used in the fields of medical devices, skin wound nursing, oral nursing, personal hygiene, environmental disinfection and the like.