Hyaluronic Acid Composition for Transdermal Absorption
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Solution Overview
Problem
Current skin care products lack effective penetration-enhancing agents that can safely and efficiently promote the absorption of active ingredients into the skin, particularly for cosmetic and dermatological applications.
Innovation Solution
A hyaluronic acid composition comprising hyaluronic acid, acetylated hyaluronic acid, and hydrolyzed hyaluronic acid, which are combined and spray-dried to create a formulation that enhances transdermal absorption of active ingredients by forming channels in the skin, allowing for improved hydration and penetration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If traditional penetration enhancers (propylene glycol, azone, menthol, borneol) are used to promote drug absorption, then the absorption rate of active ingredients is improved, but skin safety deteriorates due to adverse reactions such as sensitivity and redness
Solution Approach 1:
The patent uses hyaluronic acid and its derivatives as intermediary substances that facilitate the penetration of active ingredients into the skin without causing the harmful effects of traditional penetration enhancers. The hyaluronic acid composition acts as a mediator that opens skin barriers and promotes absorption while maintaining skin safety and biocompatibility.
Solution Approach 2:
The patent employs hyaluronic acid with different molecular weights (high, low, and oligomeric) to optimize penetration efficiency. By changing the molecular weight parameter of hyaluronic acid, the composition can effectively penetrate different skin layers while maintaining safety, avoiding the harmful effects of chemical penetration enhancers.
2Productivity
If hyaluronic acid concentration is increased to improve penetration effect, then the absorption promotion is enhanced, but the complexity of formulation increases
Solution Approach 1:
The patent creates a composite hyaluronic acid formulation containing three different types of hyaluronic acid (high molecular weight, low molecular weight, and oligomeric) with specific molecular weight distributions. This composite approach enhances penetration promotion effect while maintaining formulation simplicity through a single ingredient system rather than multiple separate components.
Solution Approach 2:
The hyaluronic acid composition serves multiple functions simultaneously: it acts as a penetration enhancer, a moisturizing agent, and a skin-conditioning ingredient. This multi-functionality reduces the need for additional formulation components, thereby simplifying the overall formulation while maintaining effective penetration promotion.
3Productivity
If complex multi-component hyaluronic acid formulations are used to enhance transdermal absorption, then the absorption rate is improved, but the ease of manufacture deteriorates
Solution Approach 1:
The patent utilizes a composite hyaluronic acid material that combines high, low, and oligomeric hyaluronic acid in a single ingredient system. This approach achieves complex penetration enhancement effects while maintaining manufacturing simplicity, as the composite material can be directly incorporated into formulations without requiring separate processing of multiple components.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The hyaluronic acid composition significantly increases the absorption rate of active ingredients, providing a synergistic effect with minimal addition, ensuring skin safety and superior hydration compared to traditional penetration enhancers.
Implementation Method 1
a hyaluronic acid composition with penetration-promoting effect
Implementation Method 2
dissolving a hyaluronic acid or a salt thereof, an acetylated hyaluronic acid or a salt thereof and a hydrolyzed hyaluronic acid or a salt thereof to obtain a solution; spray-drying the resulting solution to obtain a hyaluronic acid composition
Data Source
AI summary
Disclosed are a hyaluronic acid composition having permeation-promoting effects, a preparation method thereof and the use thereof. Provided is a hyaluronic acid composition, comprising: hyaluronic acid or a salt thereof, an acetylated hyaluronic acid or a salt thereof, and a hydrolyzed hyaluronic acid or a salt thereof. The hyaluronic acid composition of the present application has a small addition amount, can effectively facilitate the absorption of other active ingredients in a formula to achieve synergistic effects, has a small particle size, is uniform, has a fast dissolution rate, has an excellent absorption speed in a product, and is superior to hyaluronic acid treated by means of simple mixing in improving skin hydration. Compared with traditional penetration promoters, the hyaluronic acid composition of the present application causes no damage to the skin and is safe.