Hyaluronic Acid Microneedle Patch Strength and Dissolution
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Solution Overview
Problem
Conventional transdermal drug delivery methods, including microneedle patches, are not suitable for water-soluble drugs or vaccines due to the hydrophobic and negatively charged properties of the skin's stratum corneum, and existing HA-containing microneedle patches lack sufficient mechanical strength and high dissolution rates for effective skin cosmetic effects such as wrinkle reduction.
Innovation Solution
A composition comprising low-molecular HA, modified HA with histidine, and cross-linked HA, with specific weight ratios and molecular weights, is used to create a microneedle patch with enhanced mechanical strength and high dissolution rates, allowing for effective skin penetration and rapid release of HA for skin moisturizing and wrinkle reduction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If cross-linked HA is used to enhance structural strength of microneedle, then mechanical strength is improved, but dissolution rate decreases
Solution Approach 1:
The patent uses composite materials by combining cross-linked HA (for mechanical strength) with low-molecular HA and modified HA (for dissolution). This multi-component composite approach allows the microneedle to simultaneously achieve sufficient structural integrity for skin penetration and high dissolution rate for effective HA release, resolving the contradiction between strength and dissolution rate.
2Ease of operation
If direct skin application or oral administration is used for HA supplementation, then ease of operation is improved, but absorption effect deteriorates
Solution Approach 1:
The patent changes the physical state and molecular weight parameters of HA to enable transdermal delivery. By using low-molecular HA (reducing molecular weight parameter) and incorporating it into microneedle form (changing physical state), the invention achieves both ease of operation (topical application) and improved absorption effect (direct delivery to epidermis/dermis), overcoming the limitations of conventional methods.
3Reliability
If subcutaneous injection is used for HA supplementation, then absorption effect is improved, but ease of operation deteriorates due to pain and difficulty of operating
Solution Approach 1:
The patent replaces the mechanical injection system (needles, syringes, professional administration) with a microneedle patch system that dissolves on skin contact. This substitution maintains effective HA delivery (absorption effect) while eliminating the pain and operational complexity associated with subcutaneous injection, as the microneedles are so small they feel like a light tap and dissolve automatically upon skin contact.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The anti-wrinkle microneedle patch achieves good mechanical strength for skin penetration and rapid HA release, enhancing skin moisturization, thickness, and strength, while effectively reducing wrinkles, outperforming existing solutions in terms of dissolution rates and cosmetic efficacy.
Implementation Method 1
Those microneedle structures can pierce the stratum corneum of the skin, and deliver and release drugs or vaccines to the epidermis
Implementation Method 2
CN 107207784 A discloses a HA-containing microneedle patch that adopts cross-linked HA as a major material of the needle to enhance the structural strength
Implementation Method 3
after the microneedle patch penetrates the skin, the dissolution rate of releasing HA is closely related to the skin cosmetic effects
Implementation Method 4
Hyaluronic acid (HA) is highly hydrophilic and water-retaining, and is widely present in cartilage tissue, body fluids or epidermal tissue of the human body to provide elasticity and lubrication
Data Source
AI summary
Provided are an anti-wrinkle composition, an anti-wrinkle microneedle patch and a preparation method thereof. The anti-wrinkle microneedle patch comprises a base and multiple needles, the base has an upper surface, and the needles are formed on the upper surface; wherein, a material of each needle comprises a low-molecular hyaluronic acid, a modified hyaluronic acid and a cross-linked hyaluronic acid. A weight ratio of the modified hyaluronic acid to the low-molecular hyaluronic acid is 0.1 to 4, and a weight ratio of the modified hyaluronic acid to the cross-linked hyaluronic acid is less than 30. Accordingly, the anti-wrinkle microneedle patch has effects of moisturizing the skin, elevating the thickness and the strength of the skin, and smoothing and reducing the wrinkles.