Hyaluronic Acid MSM Complex for Prolonged Anti-Inflammatory Action

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Hyaluronic acid's rapid degradation by hyaluronidases limits its prolonged action in treating oxidative and inflammatory disorders, necessitating frequent administrations and potentially causing side effects.

Innovation Solution

A liquid composition comprising hyaluronic acid and methylsulfonylmethane (MSM) in a specific weight ratio, forming a non-covalent complex through a strong electrostatic bond, which slows down hyaluronic acid metabolism and increases its viscosity, allowing for prolonged action with fewer administrations.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If hyaluronic acid is administered alone, then it provides anti-inflammatory and antioxidant effects, but it undergoes rapid degradation by hyaluronidases requiring frequent administrations

Engineering Contradiction:

Improvetherapeutic effectVSAvoidduration of action

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent combines hyaluronic acid with methylsulfonylmethane (MSM) in a specific weight ratio (1:2 to 1:4) to create a composite composition. This composite approach allows the MSM to protect hyaluronic acid from hyaluronidase degradation while maintaining its therapeutic effects, thereby extending the duration of action without requiring frequent administrations.

Inventive Principle:

Principle #40Composite materials

2Reliability

If hyaluronic acid is administered frequently to maintain therapeutic effects, then reliability of treatment is improved, but side effects increase and compliance decreases

Engineering Contradiction:

Improvetherapeutic effectVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

By formulating hyaluronic acid with MSM in a composite composition, the patent reduces the frequency of administrations needed to maintain therapeutic effects. This decrease in administration frequency directly reduces the accumulation of side effects and improves patient compliance while maintaining reliable therapeutic outcomes.

Inventive Principle:

Principle #40Composite materials

3Duration of action of moving object

If hyaluronic acid is administered frequently to overcome rapid degradation, then duration of action is extended, but treatment complexity and patient burden increase

Engineering Contradiction:

Improveduration of actionVSAvoidease of use

Core Design Contradiction:

Duration of action of moving objectVSEase of operation

Solution Approach 1:

The composite composition of hyaluronic acid and MSM extends the duration of action to a single administration or reduces the frequency of administrations, thereby simplifying the treatment regimen and improving ease of use for patients.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition achieves prolonged action of hyaluronic acid, reducing the frequency of administrations and minimizing side effects, while maintaining effective physiological effects, thereby improving treatment compliance and efficacy.

Implementation Method 1

forming a non-covalent complex through a strong electrostatic bond

Methodology Applied

Scientific EffectElectrostatic bond: Electrostatics

Data Source

PatentEP3697444B1Liquid composition for use and as an Anti-inflammatory

Publication Date: 2022.03.09 ALFAKJN SRL

Figure 1a
Figure 1b
Figure 2

AI summary

The present invention relates to a composition comprising or, alternatively, consisting of an effective amount of a mixture comprising hyaluronic acid and MSM for use as an anti-inflammatory.