Hyaluronic Acid Gel Crosslinked by Sodium Trimetaphosphate for Heat Sterilization

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current hyaluronic acid (HA) based dermal fillers are less stable to heat sterilization, which is a concern for ensuring the safety and efficacy of cosmetic and aesthetic treatments.

Innovation Solution

Crosslinking hyaluronic acid with (tri)sodium trimetaphosphate (TMP) to create stable and injectable hydrogel compositions that can withstand heat sterilization, such as autoclave sterilization, while maintaining the benefits of HA in enhancing skin hydration and elasticity.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If hyaluronic acid based dermal fillers are used for cosmetic applications, then skin hydration and elasticity are enhanced, but stability to heat sterilization deteriorates

Engineering Contradiction:

Improvestability to heat sterilizationVSAvoidsterilization capability

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent applies parameter changes by modifying the chemical structure of hyaluronic acid through crosslinking with trimetaphosphate, transforming the physical and chemical parameters of the material to achieve heat sterilization stability while preserving dermal filler functionality

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention creates a composite material system by crosslinking hyaluronic acid chains with trimetaphosphate bridges, forming a stable hydrogel network that combines the biocompatibility of HA with the thermal stability of the crosslinked structure

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The TMP-crosslinked HA compositions provide stable and effective dermal fillers that can be safely sterilized and injected, improving skin conditions by maintaining hydration and elasticity, and are suitable for wrinkle filling and volumizing the face.

Implementation Method 1

Crosslinking hyaluronic acid with (tri)sodium trimetaphosphate (TMP) to create stable and injectable hydrogel compositions

Methodology Applied

Scientific EffectCrosslinking: Chemical Bonding

Implementation Method 2

The compositions are stable to heat sterilization, for example, autoclave sterilization

Methodology Applied

Scientific EffectHeat sterilization: Heating

Data Source

PatentEP2994090B1Hyaluronic acid gels crosslinked by sodium trimetaphosphate

Publication Date: 2017.12.06 ALLERGAN INDUSTRIE SAS

AI summary

Injectable dermal fillers including hyaluronic acid crosslinked with trimetaphosphate, and methods of making same are provided.