Hybrid Chromatographic Material with Superficially Porous Core
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Solution Overview
Problem
Current packing materials for liquid chromatography, particularly organic materials, suffer from low efficiency, mechanical weakness, and instability when exposed to changing mobile phase compositions, while silica-based materials lack flexibility in pH choice and show shrinking or swelling issues.
Innovation Solution
Development of inorganic/organic hybrid chromatographic materials with a superficially porous core and a surrounding material that enhances chromatographic selectivity, mechanical strength, and column efficiency, using polyorganosiloxane with functional groups like pendant alkyl amines or cyano groups for specific applications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If organic materials are used for chromatographic packing, then chemical stability against strongly alkaline and acidic mobile phases is improved, but column efficiency and mechanical strength deteriorate
Solution Approach 1:
The patent employs composite materials by combining organic polymer materials with inorganic materials (such as silica particles or metal oxides) to create hybrid chromatographic packing materials. This composite structure allows the organic component to provide chemical stability against extreme pH conditions while the inorganic component contributes to enhanced mechanical strength and column efficiency, thereby resolving the contradiction between chemical stability and productivity.
2Adaptability or versatility
If organic materials are used for chromatographic packing, then flexibility in mobile phase pH choice is improved, but mechanical strength and stability against composition changes deteriorate
Solution Approach 1:
The hybrid composite structure combines the pH flexibility of organic materials with the mechanical strength of inorganic materials. The organic polymer matrix maintains flexibility in mobile phase pH selection, while the embedded inorganic particles provide structural support and resistance to swelling or shrinking when mobile phase composition changes, thus resolving the contradiction between adaptability and strength.
3Productivity
If silica-based materials are used for chromatographic packing, then column efficiency is improved, but flexibility in pH choice and mechanical stability deteriorate
Solution Approach 1:
The patent reverses the traditional silica-based approach by using an organic polymer matrix with embedded inorganic particles. This inversion allows the organic component to provide flexibility in pH choice and the inorganic component to contribute to column efficiency, thereby resolving the contradiction between productivity and adaptability.
4Productivity
If silica-based materials are used for chromatographic packing, then high column efficiency is improved, but shrinking and swelling when mobile phase composition changes deteriorates
Solution Approach 1:
The hybrid composite structure combines an organic polymer matrix with inorganic particles to achieve dimensional stability. The organic component provides flexibility and resistance to swelling, while the inorganic particles maintain structural integrity and prevent shrinking, thereby resolving the contradiction between productivity and compositional stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The hybrid materials provide enhanced chromatographic selectivity and stability, maintaining efficiency and mechanical strength across varying pH conditions, offering improved performance for separating small molecules, proteins, and DNA.
Implementation Method 1
condensing one or more polymeric organofunctional metal precursors, and/or polymeric metal oxide precursors on the surface of the superficially porous core
Implementation Method 2
Differences in hydrophobicity, ion-exchange capacity, surface charge or silanol activity of the surrounding material may be used for unique chromatographic separations
Implementation Method 3
selecting a polyorganosiloxane (POS) with functional groups (e.g., pendant alkyl amines, alcohols, carboxylic acids, alkene or cyano group) that are relevant for a given chromatographic application
Data Source
AI summary
The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for their preparation and separations devices containing the chromatographic materials. The preparation of the inorganic/organic hybrid materials of the invention wherein a surrounding material is condensed on a superficially porous hybrid core material will allow for families of different hybrid packing materials to be prepared from a single core hybrid material. Differences in hydrophobicity, ion-exchange capacity, chemical stability, surface charge or silanol activity of the surrounding material may be used for unique chromatographic separations of small molecules, carbohydrates, antibodies, whole proteins, peptides, and/or DNA.