Hybrid Corn CH010499 Breeding for Genetic Stability

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Solution Overview

Problem

Existing corn breeding techniques struggle to develop hybrids with uniformity and desirable traits such as higher yield, disease resistance, and improved agronomic qualities, while maintaining genetic stability and efficiency in hybrid production.

Innovation Solution

The development of the hybrid corn variety CH010499, which incorporates genetic modifications and cytoplasmic traits like male sterility, along with specific breeding methods and tissue culture techniques to enhance traits like herbicide resistance, disease resistance, and improved growth characteristics, is achieved through backcrossing and genetic editing using engineered nucleases.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If traditional corn breeding techniques are used, then hybrid development is achieved, but uniformity and genetic stability are difficult to maintain

Engineering Contradiction:
ImproveuniformityVSAvoidbreeding process complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The patent applies preliminary action by developing homozygous inbred lines through multiple generations of self-pollination and selection before creating the hybrid. This preliminary inbreeding process ensures genetic uniformity and stability in the parent lines, which then produce uniform F1 hybrids when crossed, resolving the contradiction between achieving uniformity and the complexity of the breeding process.

Inventive Principle:
Principle #10Preliminary action

2Productivity

If multiple desirable traits are combined in a single hybrid, then agricultural productivity improves, but genetic stability and uniformity become harder to maintain

Engineering Contradiction:
Improveagricultural productivityVSAvoidgenetic stability
Core Design Contradiction:
ProductivityVSStability of the object's composition

Solution Approach 1:

The patent applies segmentation by dividing the breeding process into separate stages: first developing homozygous inbred lines with specific desirable traits through self-pollination, then crossing these stabilized lines to create hybrids. This segmentation allows each stage to focus on specific traits while maintaining genetic stability through homozygosity in the parent lines, enabling multiple desirable traits to be combined in F1 hybrids without compromising overall genetic stability.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent utilizes parameter changes by transitioning from homozygous parent lines to heterozygous F1 hybrids, exploiting the heterosis effect. This parameter change in genotype (from homozygous to heterozygous) allows the combination of multiple desirable traits while maintaining uniformity and stability in the hybrid population, as all F1 hybrids from uniform parents will be genetically identical.

Inventive Principle:
Principle #35Parameter changes

3Manufacturing precision

If hybrid corn varieties are developed through conventional breeding, then yield and quality improve, but development time and efficiency are reduced

Engineering Contradiction:
Improveagronomic qualityVSAvoidbreeding cycle time
Core Design Contradiction:
Manufacturing precisionVSLoss of time

Solution Approach 1:

The patent applies copying by using tissue culture techniques to produce multiple copies of homozygous inbred lines and F1 hybrids from single parent plants. This copying method dramatically reduces the time required to generate large populations of uniform plants compared to conventional field-based breeding, while maintaining the desired agronomic qualities and genetic uniformity through clonal propagation.

Inventive Principle:
Principle #26Copying

Data Source

PatentUS20250204353A1Plants and seeds of hybrid corn variety ch010499
Publication Date: 2025.06.26 MONSANTO TECHNOLOGY LLC

AI summary

According to the disclosure, there is provided seed and plants of the hybrid corn variety designated CH010499. The disclosure thus relates to the plants, seeds, and tissue cultures of the variety CH010499, and to methods for producing a corn plant produced by crossing a corn plant of variety CH010499 with itself or with another corn plant, such as a plant of another variety. The disclosure further relates to genetic complements of plants of variety CH010499.