Hydratable Bone Putty With Porous Ceramics for Cohesive Flowability

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Solution Overview

Problem

Existing bone cements and putties face challenges in maintaining cohesive stability and flexibility for handling and conversion between putty, paste, non-settable flowable cement, and gel forms, with ceramics being difficult to incorporate and disrupting the composition's integrity.

Innovation Solution

A composition comprising porous ceramic granules with hydroxyapatite and beta-tricalcium phosphate, ranging from 50 μm to 800 μm, and a collagen carrier, which can be hydrated to form stable putties, non-settable flowable cements, or gels, and vice versa, allowing for moldable and flowable administration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If large hard ceramic pieces are added to the composition to enhance bone growth, then bone growth is improved, but the composition becomes unstable and lacks cohesiveness for handling

Engineering Contradiction:

Improvebone growthVSAvoidcohesiveness

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent uses porous ceramic granules instead of solid ceramic pieces. The porous structure allows the ceramic to maintain bone growth properties while being incorporated into a cohesive polymer matrix. The granules are distributed throughout the putty without disrupting its cohesiveness, enabling both bone growth enhancement and stable handling characteristics.

Inventive Principle:

Principle #31Porous materials

Solution Approach 2:

The patent creates a composite material combining ceramic granules with a biodegradable polymer matrix. This composite structure allows the ceramic components to provide bone growth stimulation while the polymer matrix maintains cohesiveness and handling properties. The synergistic combination resolves the contradiction between ceramic benefits and compositional stability.

Inventive Principle:

Principle #40Composite materials

2Ease of operation

If additional fluid is added to an already formed bone putty to create non-settable flowable cement, then flowability is improved, but the over hydrated putty lacks cohesion and disintegrates

Engineering Contradiction:

ImproveflowabilityVSAvoidcohesion

Core Design Contradiction:

Ease of operationVSStability of the object's composition

Solution Approach 1:

The patent creates a dynamic composition that can transition between different states. The putty can be hydrated to form a flowable cement state for injection, and the formulation allows this transition without loss of cohesion. The controlled hydration process enables the material to adapt its consistency for different administrative methods while maintaining structural integrity.

Inventive Principle:

Principle #15Dynamics

Solution Approach 2:

The patent utilizes parameter changes in the polymer matrix to control the transition between putty and flowable cement states. By adjusting hydration parameters and polymer properties, the material can transition between cohesive putty form and flowable cement form without disintegration, enabling versatile administration methods.

Inventive Principle:

Principle #35Parameter changes

3Ease of operation

If the composition is made to be flowable for cannula administration, then ease of administration is improved, but the composition may not maintain stability after implantation

Engineering Contradiction:

Improveease of administrationVSAvoidstability after implantation

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

Inventive Principle:

Principle #15Dynamics

Solution Approach 2:

The patent uses a biodegradable polymer matrix that is designed to be temporarily present in the body. The polymer provides the necessary structural integrity during administration and then naturally degrades, allowing the ceramic granules to be fully integrated into the bone healing process. This approach ensures stability during administration followed by beneficial degradation for bone regeneration.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition provides stable and flexible handling characteristics, enabling seamless conversion between forms and effective administration to bone defects, enhancing bone growth and repair.

Implementation Method 1

The porous ceramic granules have an average diameter from about 50 μm to 800 μm and comprise hydroxyapatite and beta-tricalcium phosphate

Methodology Applied

Scientific EffectCapillary action: Capillary Action

Implementation Method 2

The composition further includes a collagen carrier

Methodology Applied

Scientific EffectAdsorption: Adsorption

Data Source

PatentUS12599696B2Hydratable and flowable implantable compositions and methods of making and using them

Publication Date: 2026.04.14 WARSAW ORTHOPEDIC INC

AI summary

Implantable bone compositions are provided. The implantable compositions comprise hydratable bone putties. The hydratable bone putties comprise porous ceramic granules having an average diameter from about 50 μm to 800 μm and the composition has a texture value above about 1000. The porous ceramic granules comprise hydroxyapatite and beta-tricalcium phosphate. The implantable bone compositions further include collagen carriers. In some embodiments, the hydratable bone putty can be hydrated to form a non-settable flowable cohesive cement or gel. Methods of making and using the implantable compositions are also provided.