Partially Hydrated Zeolite Hemostatic Agent for Traumatic Bleeding Control
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Solution Overview
Problem
Existing blood clotting materials are ineffective in severe wounds, particularly in remote or battlefield situations, due to high cost, difficulty in application and removal, and undesirable side effects, and they often fail to control bleeding effectively.
Innovation Solution
A composition comprising a zeolite and a binder with adjusted moisture content to reduce heat transfer upon application, allowing for controlled exothermic effects and enhanced clot formation, using a molecular sieve that absorbs blood components to promote clotting.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional blood clotting materials are used, then bleeding control may be achieved, but they are expensive and ineffective in severe wounds
Solution Approach 1:
The patent changes the moisture content parameter of the zeolite from conventional low levels (1.54% or less) to optimized levels (2-10%), which dramatically improves clotting effectiveness in severe wounds while maintaining cost-effectiveness through the use of readily available zeolite materials
Solution Approach 2:
The patent creates a composite material system combining zeolite with specific binders (starch, cellulose, or collagen) to achieve superior hemorrhage control in severe wounds compared to conventional single-material approaches
2Productivity
If zeolite is applied to blood, then water is adsorbed and heat is generated, but excessive heat can damage surrounding tissue
Solution Approach 1:
The patent pre-hydrates the zeolite before application to establish thermal balance, so that when applied to blood, the exothermic reaction occurs at reduced intensity and does not cause thermal damage to surrounding tissues
Solution Approach 2:
The patent optimizes the moisture content parameter of the zeolite to control the heat generation rate, balancing the need for rapid clot formation with the requirement to prevent thermal injury to surrounding tissues
3Quantity of substance
If fully dehydrated zeolite is used, then maximum water adsorption capacity is achieved, but excessive heat is generated upon application
Solution Approach 1:
The patent pre-hydrates the zeolite to a controlled extent before application, reducing the subsequent exothermic reaction intensity while maintaining sufficient water adsorption capacity for effective clotting in severe wounds
4Reliability
If conventional clotting materials are applied, then clotting may occur, but application and removal are difficult
Solution Approach 1:
The patent forms the zeolite-binder composition into flexible wafer structures that are easy to apply and remove, overcoming the operational difficulties of conventional clotting materials while maintaining high clotting effectiveness
Solution Approach 2:
The patent optimizes the binder composition and moisture content to achieve the right balance between clotting effectiveness and ease of application/removal, creating a material that is both highly effective and user-friendly
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively clots traumatic bleeding with reduced heat transfer to the wound, demonstrated in a lethal femoral swine model with a 0% morbidity rate, outperforming other materials and maintaining product efficacy.
Implementation Method 1
water in the blood is adsorbed by the zeolite
Implementation Method 2
Upon adsorption of this water, heat is generated
Data Source
AI summary
A composition for promoting the formation of clots in blood comprises a zeolite and a binder. The zeolite is adjusted to have a specific moisture content. Processes by which the moisture content is adjusted include drying, re-hydrating, and combinations of drying and re-hydrating. A method of forming the composition comprises the steps of providing a zeolite and adjusting the moisture content such that upon application of the composition to a wound, a heat of hydration is reduced and heat transferred to the wound is reduced. A method of clotting blood flowing from a wound comprises the steps of applying the zeolite to the wound and maintaining the zeolite in contact with the wound for a predetermined amount of time, the zeolite having an adjusted moisture content and being capable of producing a controllable exothermic effect on the wound.