Photocrosslinked Hydrogel Blended Composition for Wound Adhesion
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Solution Overview
Problem
Commercially available photopolymerized hydrogel prepolymers for cell therapy have low viscosity and yield stress at physiological temperatures, causing them to flow away when applied to non-horizontal or uneven surfaces, such as intestinal walls or wounds.
Innovation Solution
A hydrogel blended composition comprising a photopolymerizable monomer, a photopolymerizable gel-forming component, and a photoinitiator, which undergoes photocrosslinking polymerization to form a hydrogel with high viscosity and yield stress, allowing for better adhesion and retention on inclined or curved surfaces, and can be reactivated to form a gel upon exposure to specific wavelengths of light.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If photopolymerizable monomer and gel-forming component are used to create hydrogel for cell therapy, then the hydrogel can be applied to wounds and intestinal walls, but the low viscosity and yield stress at physiological temperature cause the hydrogel to flow away from non-horizontal or uneven surfaces
Solution Approach 1:
The patent applies parameter changes by modifying the chemical composition parameters of the hydrogel system. Specifically, it uses a photopolymerizable monomer (such as glycidyl methacrylate) combined with a photopolymerizable gel-forming component (such as gelatin methacryloyl) in specific molar ratios (1:2 to 1:10). This compositional parameter change enables the hydrogel to achieve high viscosity and yield stress at physiological temperature while maintaining applicability to complex wound surfaces.
Solution Approach 2:
The patent implements preliminary action through the use of a photopolymerizable monomer that remains in unreacted form before light exposure. This unreacted monomer acts as a viscosity-enhancing agent in the prepolymer solution, allowing the mixture to maintain high viscosity and yield stress before application. Upon exposure to light, the monomer polymerizes and crosslinks with the gel-forming component, locking in the desired high-viscosity state and preventing flow away from the application site.
2Area of stationary object
If the hydrogel is applied to non-horizontal or uneven surfaces, then it can cover the wound area, but the low yield stress causes it to flow away
Solution Approach 1:
The patent applies composite materials by combining a photopolymerizable monomer with a photopolymerizable gel-forming component to create a blended composition. This composite system synergistically combines the viscosity-enhancing properties of the unreacted monomer with the gel-forming capabilities of the gel-forming component, resulting in a material that maintains high yield stress and stability on inclined or uneven surfaces while still achieving complete wound coverage.
3Adaptability or versatility
If the hydrogel prepolymer solution is applied to wounds and then polymerized, then it provides better matching of wound shape and allows on-site customization, but the low viscosity causes it to flow away before polymerization
Solution Approach 1:
The patent applies parameter changes by modifying the chemical composition to include a photopolymerizable monomer that significantly increases the viscosity parameter of the prepolymer solution. This parameter change allows the solution to maintain its position on wound surfaces with complex geometries, enabling complete shape matching and on-site customization without the solution flowing away before polymerization can occur.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The hydrogel composition significantly increases viscosity and cohesion, enabling effective application and retention on complex surfaces, and can be easily reformed for repeated use, enhancing its utility in wound repair and cell culture applications.
Implementation Method 1
irradiating the colloidal mixture with the light of a wavelength capable of photopolymerization, so that the colloidal mixture undergoes photocrosslinking polymerization to form a hydrogels blended composition
Implementation Method 2
a crosslinked hydrogel polymer, wherein the crosslinked hydrogel polymer refers to the hydrogel polymer produced by the photopolymerization reaction of the hydrogel prepolymer and a photoinitiator
Data Source
AI summary
The present invention discloses a partially crosslinked hydrogels blended composition with enhanced viscosity and yield stress, which is formed by the polymerization of one or more colloid monomers through crosslinking. The polymerization is initiated by a photoinitiator under irradiation of the light of a specific wavelength, which promotes crosslinking of the one or more colloid monomers. The hydrogels blended composition can be further crosslinked with one or more other colloid monomers through repeated excitation of the photoinitiator. The hydrogels blended composition can be polymerized into a gel upon re-irradiation, and can also be used as a biomaterial for wound repair, three-dimensional cell culture, personal nursing care, health care, medical and pharmaceutical applications.