Synthetic Hydrogel Composites for Enterosorptive Toxin Removal
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Solution Overview
Problem
Current methods are inadequate for in vivo removal of carcinogens, carcinogen precursors, nitrosamines, nitrates, PFAS, and synthetic food dyes from the human body, as they are either ineffective or not suitable for in vivo applications.
Innovation Solution
Development of synthetic-based hydrogels and hydrogel composites that can be orally administered to bind and remove these harmful substances from the digestive tract without being metabolized or absorbed into systemic circulation, using hydrogel base materials like poly(ethylene glycol) and functional co-monomers such as (3-acrylamidopropyl)trimethylammonium chloride, along with additives like activated carbon.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current methods are used for removal of carcinogens and harmful substances, then the existing treatment approaches can be applied, but they are ineffective or not suitable for in vivo applications
Solution Approach 1:
The patent introduces an intermediary substance (enterosorbent composition) that mediates between the harmful substances in the digestive tract and the body's natural excretion processes. This composition binds to carcinogens, nitrosamines, nitrates, PFAS, and synthetic food dyes, enabling their removal without requiring direct metabolic processing by the body, thus resolving the contradiction between effectiveness and in vivo suitability
Solution Approach 2:
The invention employs a composite material comprising hydrogel base material and functional co-monomer that combines the properties of different components to achieve both high binding effectiveness for multiple types of harmful substances and biocompatibility for in vivo use. The composite structure allows simultaneous targeting of diverse carcinogens and their precursors while maintaining safety for oral administration
2Reliability
If synthetic-based hydrogels are used to bind harmful substances, then binding effectiveness is improved, but the complexity of the material composition increases
Solution Approach 1:
The synthetic-based hydrogel composition is designed with multi-functionality to bind multiple types of harmful substances (carcinogens, nitrosamines, nitrates, PFAS, synthetic food dyes) through a single material system. The functional co-monomer components provide diverse binding mechanisms that can simultaneously target different chemical structures, reducing the need for multiple specialized materials while maintaining high binding effectiveness across various toxin types
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The hydrogels effectively bind and remove carcinogens, carcinogen precursors, nitrosamines, nitrates, PFAS, and synthetic food dyes from the digestive tract, providing a direct and efficient method for mitigating their health impacts.
Implementation Method 1
the synthetic-based hydrogel or synthetic-based hydrogel composite is adapted to bind and remove the target molecule from the digestive track
Implementation Method 2
along with additives like activated carbon
Data Source
AI summary
A method for enterosorptive removal of a target molecule from a digestive tract of an individual, includes orally administering to the individual a synthetic-based hydrogel or synthetic-based hydrogel composite incorporating a hydrogel base material and a functional co-monomer. The synthetic-based hydrogel or synthetic-based hydrogel composite is adapted to bind and remove the target molecule from the digestive track without being metabolized or absorbed into systemic circulation.