Placental Tissue Hydrogel Graft for Wound Exudate Control

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Solution Overview

Problem

Current wound dressings derived from placental tissues, such as amnion and chorion, fail to effectively manage excessive wound exudate, which can impede healing by overhydrating the wound, inhibiting fibroblast production, increasing infection risk, and prolonging the inflammatory phase.

Innovation Solution

Incorporating a swellable hydrogel and a (super) absorbent material into wound dressings to regulate exudate, with the hydrogel wicked into the wound bed to absorb excess fluid and the absorbent material retaining it, reducing infection risk and promoting healing.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If placental tissue grafts are used as wound dressings, then wound healing is promoted through biological properties, but excessive exudate cannot be managed leading to overhydration and delayed healing

Engineering Contradiction:

Improvewound healing promotionVSAvoidexcessive exudate management

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent combines placental tissue graft with hydrogel and absorbent material layers to create a composite wound dressing that integrates the biological healing properties of placental tissue with the exudate absorption capabilities of hydrogel and absorbent materials, thereby simultaneously achieving wound healing promotion and excessive exudate management

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The wound dressing is constructed as a composite structure comprising placental tissue, hydrogel, and absorbent material layers, where each material contributes its unique properties: placental tissue provides biological healing factors, hydrogel provides moisture retention and exudate absorption, and absorbent material provides bulk exudate management, together resolving the contradiction between promoting healing and managing exudate

Inventive Principle:

Principle #40Composite materials

2Productivity

If a moist wound environment is maintained for optimal healing, then cell proliferation is enhanced, but over-production of exudate leads to overhydration and infection risk

Engineering Contradiction:

Improvecell proliferation rateVSAvoidinfection risk from overhydration

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent uses hydrogel to dynamically adjust the moisture parameters of the wound environment, allowing the material to absorb excess exudate while maintaining adequate moisture levels, thereby keeping the wound environment within the optimal range for cell proliferation without transitioning to overhydrated conditions that increase infection risk

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The hydrogel and absorbent material layers act as feedback mechanisms that respond to exudate production levels by absorbing excess fluid, thereby automatically regulating the wound environment to maintain optimal moisture for cell proliferation while preventing overhydration and associated infection risks

Inventive Principle:

Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The combination of swellable hydrogel and absorbent material effectively manages exudate, reducing infection risk and promoting wound healing by maintaining a controlled environment.

Implementation Method 1

a second portion adjacent the first portion, comprising a swellable hydrogel

Methodology Applied

Scientific EffectHydrogel swelling: Hydrogel

Implementation Method 2

the hydrogel wicked into the wound bed to absorb excess fluid

Methodology Applied

Scientific EffectAbsorption: Absorption (physical)

Implementation Method 3

the absorbent material retaining it

Methodology Applied

Scientific EffectCapillary action: Capillary Action

Data Source

PatentUS20250387542A1Swellable hydrogel graft for exudate control

Publication Date: 2025.12.25 TIDES MEDICAL LLC

AI summary

This disclosure generally relates to grafts having exudate control for treating a wound of a subject and methods thereof. In some embodiments, the grafts comprising a first layer comprising a first portion and a second portion. In some embodiments, the first portion comprises amnion, chorion, or a combination thereof. In some embodiments, the second portion comprises a swellable hydrogel. In other embodiments, the grafts comprise a first layer comprising amnion, chorion, or a combination thereof and a second layer, disposed on the first layer, comprising the swellable hydrogel. Additionally, in some embodiments, the grafts may further comprise one or more additional layers, for example, a third layer, adjacent the second layer, comprising an adsorbent material; and/or an adhesive fourth layer adjacent the third layer for adhering said graft to the skin of a subject. Other embodiments are directed toward methods of bonding two or more layers within the graft.