Hydrogel Microparticles Sustained Nutrient Release

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Athletes face challenges in maintaining sustained and controlled supply of carbohydrates and other nutrients for enhanced performance and recovery, as existing sports drinks often require frequent intake and can lead to excessive glycemic response.

Innovation Solution

Development of an aqueous suspension containing hydrogel microparticles that encapsulate nutritional supplements like carbohydrates, amino acids, and electrolytes, providing a sustained release over extended periods through controlled release mechanisms using biodegradable polymers and crosslinking methods, maintaining optimal absorption rates and reducing insulin response.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of moving object

If conventional sports drinks are consumed to provide carbohydrates and nutrients, then athletic performance can be improved, but frequent intake is required and excessive glycemic response occurs

Engineering Contradiction:
Improveduration of nutrient supplyVSAvoidfrequency of intake
Core Design Contradiction:
Duration of action of moving objectVSEase of operation

Solution Approach 1:

The patent applies preliminary action by pre-encapsulating carbohydrates and nutrients in hydrogel microparticles with controlled release mechanisms before consumption. The hydrogel matrix is designed to release nutrients at a controlled rate over time, eliminating the need for frequent re-dosing. This preliminary structuring of the nutrient delivery system ensures sustained release throughout the athletic event without requiring repeated intake actions.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent utilizes parameter changes by modifying the physical and chemical properties of the hydrogel matrix (crosslinking density, polymer composition, mesh size) to control the release rate of nutrients. By adjusting these parameters, the system achieves a sustained release profile that maintains optimal carbohydrate absorption rates over extended periods, thereby extending the duration of action and reducing the frequency of intake required.

Inventive Principle:
Principle #35Parameter changes

2Quantity of substance

If large amounts of food are consumed to meet dietary requirements, then sustained nutrient supply is achieved, but excessive glycemic response and insulin spikes occur

Engineering Contradiction:
Improveamount of carbohydratesVSAvoidglycemic response
Core Design Contradiction:
Quantity of substanceVSObject-generated harmful factors

Solution Approach 1:

The patent applies segmentation by dividing the total carbohydrate load into numerous small microparticles that release nutrients gradually. Instead of consuming a large amount of food or concentrated sugar solution that would cause a glycemic spike, the carbohydrates are segmented into individual hydrogel microparticles that release small amounts of glucose over time. This segmentation of the nutrient delivery system maintains blood glucose levels within optimal ranges without excessive spikes.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The hydrogel matrix serves as an intermediary between the consumed carbohydrates and the bloodstream. Rather than carbohydrates entering the bloodstream directly and causing rapid glycemic response, the hydrogel acts as a rate-limiting barrier that controls the release kinetics. This intermediary structure allows the system to deliver the necessary quantity of carbohydrates while preventing excessive glycemic response by regulating the rate of delivery.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Object-generated harmful factors

If frequent small amounts of sports drink are consumed, then glycemic response is reduced, but sustained nutrient supply is compromised

Engineering Contradiction:
Improveglycemic peaksVSAvoidsustained performance enhancement
Core Design Contradiction:
Object-generated harmful factorsVSDuration of action of moving object

Solution Approach 1:

The patent implements continuity of useful action by designing the hydrogel microparticles to provide continuous, sustained release of carbohydrates throughout the athletic event. The controlled release mechanism ensures a steady stream of glucose is delivered to the bloodstream without interruption or significant fluctuations, maintaining continuous fuel supply for muscle metabolism. This continuous action extends performance enhancement duration without creating glycemic peaks, as the release rate is matched to utilization rate.

Inventive Principle:
Principle #20Continuity of useful action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution significantly increases exercise duration, cumulative power output, and reduces recovery time, offering improved athletic performance by maintaining peak carbohydrate absorption and oxidation rates, with enhanced energy sustainability and reduced glycemic peaks.

Implementation Method 1

one or more hydrogel microparticles that encapsulate one or more nutritional supplements

Methodology Applied
Scientific EffectDiffusion: Diffusion

Implementation Method 2

biodegradable polymers and crosslinking methods, maintaining optimal absorption rates

Methodology Applied
Scientific EffectBiodegradation: Decomposition (biological)

Implementation Method 3

The crosslinked polysaccharides are crosslinked using a divalent cation, e. g. calcium, as a result of which the crosslinking is ionic

Methodology Applied
Scientific EffectIonic crosslinking: Chemical Bonding

Implementation Method 4

a cooked and hydrated carbohydrate core and a cation crosslinked polysaccharide coating

Methodology Applied
Scientific EffectGel formation: Gel

Data Source

PatentEP2389075B1Sustained release of nutrients in vivo
Publication Date: 2017.11.15 NEW WORLD PHARMACEUTICALS LLC
  • EP2389075B1 patent drawingFigure 1
  • EP2389075B1 patent drawingFigure 2~3
  • EP2389075B1 patent drawingFigure 4~5

AI summary

Nutritional compositions delivered in vivo ina time controlled manner sustainable over long periods of time, provide enhancing athletic performance, increased hand/eye coordination and concentration on the task at hand.