Polysaccharide-Collagen Hydrogel Scaffold for Long-Term Cell Viability
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Solution Overview
Problem
Current wound care products, particularly hydrogels, face challenges with limited cell compatibility, biodegradability, and immunogenicity, and lack effective solutions for long-term cell growth and viability.
Innovation Solution
A hydrogel comprising a gellan gum polymer network and collagen, with an interpenetrating polymer network (IPN) structure, and optionally incorporating chlorella growth factor, to enhance cell survival and proliferation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If synthetic hydrogels are used, then mechanical properties and water content are improved, but cell compatibility and biodegradability deteriorate
Solution Approach 1:
The patent combines gellan gum (natural polysaccharide) with synthetic polymer components to create a composite hydrogel system. This composite structure integrates the biocompatibility and biodegradability of natural polymers with the mechanical strength and structural stability of synthetic polymers, resolving the contradiction between mechanical properties and cell compatibility
2Reliability
If animal-derived materials are used, then cell growth support is improved, but immunogenicity and infection risk worsen
Solution Approach 1:
The patent introduces gellan gum as an intermediary natural polysaccharide that provides cell growth support functions typically associated with animal-derived materials, while eliminating the immunogenicity and infection risks. The gellan gum matrix is engineered to incorporate cell adhesion peptides that mediate cell attachment and proliferation without the harmful factors of animal products
3Reliability
If simple gellan gum hydrogel is used, then biocompatibility is improved, but long-term cell growth and viability worsen
Solution Approach 1:
The patent merges gellan gum hydrogel with collagen and cell adhesion peptides to create an enhanced composite hydrogel. This combination maintains the biocompatibility of gellan gum while adding the cell growth support capabilities of collagen and the specific cell anchorage functions of adhesion peptides, enabling long-term cell survival and proliferation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The hydrogel supports long-term cell survival and proliferation, providing an optimal microenvironment for wound healing and cell growth, with improved mechanical properties and enhanced wound healing potential.
Implementation Method 1
Hydrogels are made up of physically or chemically crosslinked polymers derived from natural or synthetic sources
Implementation Method 2
Hydrogels are made up of physically or chemically crosslinked polymers
Implementation Method 3
the gel can function particularly effectively to take up water e.g. wound exudate in use of the dressing
Implementation Method 4
the presence of collagen at low concentration remarkably improved the long-term survival of cells
Data Source
Figure 1
Figure 2A~2F
Figure 3A
AI summary
The present invention relates to a hydrogel comprising polysaccharide polymer network and collagen, particularly for use in the wound treatment. The present invention also relates to a wound dressing and a cell culture system comprising the hydrogel and their use in the wound treatment.