Hydrogen Dissolution Device for Dialysate Production

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Solution Overview

Problem

The concentration of dissolved hydrogen in dialysate supplied to dialysis devices decreases during the manufacturing process, affecting the efficacy of hemodialysis treatments.

Innovation Solution

An apparatus incorporating a reverse osmosis membrane treatment device, a dialysate supply device, and a hydrogen dissolution device with an air supply module and hydrogen supply device to dissolve hydrogen gas in the dialysate, ensuring consistent hydrogen concentration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If dialysate source reagent containing hydrogen gas is mixed with other dialysate source reagent and then diffused, then dialysate can be prepared, but the concentration of dissolved hydrogen in acral dialysate decreases

Engineering Contradiction:
Improvedissolved hydrogen concentrationVSAvoidhydrogen concentration loss during mixing
Core Design Contradiction:
Quantity of substanceVSLoss of substance

Solution Approach 1:

The patent applies preliminary action by dissolving hydrogen gas into the dialysate source reagent A before mixing with reagent B. The hydrogen dissolution device is configured to dissolve hydrogen in advance, so that when mixing occurs, the hydrogen concentration is already established and protected from loss during the diffusion process.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent uses a hydrogen dissolution device as an intermediary component between the reagent mixing process and the final dialysate output. This device acts as a mediator that maintains hydrogen concentration by continuously dissolving hydrogen into the dialysate stream, compensating for any concentration loss during mixing and diffusion.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Object-affected harmful factors

If hydrogen gas is dissolved in dialysate source reagent before mixing, then oxidative stress can be reduced, but the hydrogen concentration decreases during diffusion

Engineering Contradiction:
Improveoxidative stressVSAvoiddissolved hydrogen concentration
Core Design Contradiction:
Object-affected harmful factorsVSQuantity of substance

Solution Approach 1:

The patent implements continuity of useful action by configuring the hydrogen dissolution device to continuously dissolve hydrogen into the dialysate throughout the manufacturing process. This continuous action ensures that hydrogen concentration is maintained at therapeutic levels despite the diffusion process, thereby continuously providing protection against oxidative stress.

Inventive Principle:
Principle #20Continuity of useful action

Solution Approach 2:

The system incorporates feedback mechanisms where the hydrogen dissolution device monitors and adjusts hydrogen dissolution based on the dialysate flow and concentration requirements. This feedback control ensures that hydrogen concentration is maintained at optimal levels for reducing oxidative stress while compensating for losses during mixing and diffusion.

Inventive Principle:
Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Effectively reduces the decrease in dissolved hydrogen concentration in acral dialysate, maintaining optimal hydrogen levels for effective hemodialysis.

Implementation Method 1

a reverse osmosis membrane treatment device configured to perform reverse osmosis membrane treatment to water

Methodology Applied
Scientific EffectReverse osmosis: Reverse Osmosis

Implementation Method 2

a hydrogen dissolution device configured to dissolve hydrogen gas in the dialysate

Methodology Applied
Scientific EffectGas dissolution: Absorption (physical)

Data Source

PatentEP3842082B1Dialysis solution production device
Publication Date: 2022.11.16 NIHON TRIM KO LTD
  • EP3842082B1 patent drawingFigure 1
  • EP3842082B1 patent drawingFigure 2
  • EP3842082B1 patent drawingFigure 3

AI summary

The apparatus (1) for manufacturing dialysate includes a reverse osmosis membrane treatment device (9), a dialysate supply device (26), a dialysis device (40) supplied with the dialysate (27) from the dialysate supply device (26), and a hydrogen dissolution device (6) interposed between the dialysate supply device (26) and the dialysis device (40) and configured to dissolve hydrogen gas in the dialysate (27). The hydrogen dissolution device (6) includes an air supply module (7) connected to the dialysate supply device (26) and configured to dissolve hydrogen gas in the dialysate (27), and a hydrogen supply device (8) connected to the air supply module (7) and configured to supply hydrogen gas to the air supply module (7).