Inhalation Composition Using Hydrogen to Reduce Gastrointestinal Side Effects
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Solution Overview
Problem
Current treatments for arthritis, such as non-steroidal anti-inflammatory drugs, effectively relieve pain but cause gastrointestinal side effects due to strong stimulation of the digestive tract, lacking a balance between curative effect and reduced side effects.
Innovation Solution
An inhalation-type pharmaceutical composition combining hydrogen gas with atomized medications like indomethacin, flurbiprofen, or celecoxib, where the hydrogen gas concentration is controlled between 2 to 96%, generated through electrolysis or mixed with other gases to optimize absorption and minimize side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If non-steroidal anti-inflammatory drugs are used to treat arthritis, then pain relief and anti-inflammatory effects are improved, but gastrointestinal side effects worsen due to strong stimulation of the digestive tract
Solution Approach 1:
Hydrogen gas serves as an intermediary substance that neutralizes harmful radicals in the gastrointestinal tract. The hydrogen molecules react with reactive oxygen species and free radicals generated by NSAID stimulation, converting them into harmless water molecules, thereby protecting the digestive mucosa from damage while maintaining the anti-inflammatory efficacy of the medication
Solution Approach 2:
The harmful radicals and oxidative stress caused by NSAID treatment are converted into beneficial effects through hydrogen's antioxidant properties. By introducing hydrogen gas, the harmful oxidative damage is transformed into a protective mechanism where excess radicals are neutralized, turning the previously harmful oxidative environment into a therapeutic advantage that reduces gastrointestinal irritation
2Productivity
If atomized medicine is used instead of conventional administration, then medication absorption is improved, but device complexity increases due to atomization equipment requirements
Solution Approach 1:
The atomization function is merged with the existing inhalation device structure. The atomization mechanism is integrated into the inhaler body, combining drug delivery and aerosol generation into a single unified device, thereby improving absorption without proportionally increasing overall device complexity
Solution Approach 2:
The inhalation device is designed with multi-functionality, serving both as a conventional inhaler and as an atomization system. The same device structure performs multiple functions: holding the medication, generating aerosol particles, and delivering them to the patient, thereby achieving enhanced absorption while avoiding the need for separate complex atomization equipment
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides effective arthritis treatment with enhanced medication absorption and reduced gastrointestinal side effects by using hydrogen to neutralize harmful radicals, offering a convenient and curative solution.
Implementation Method 1
through the use of hydrogen while also increases the absorption effect of the medicine for the patient by using an atomized medicine
Implementation Method 2
the first gas is a gas mixture of hydrogen and oxygen generated from electrolyzing water, where the volume ratio of hydrogen to oxygen is 2:1
Implementation Method 3
atomizing a medicinal liquid in order to generate an atomized medicine, wherein the atomized medicine is selected from a group comprising indomethacin, flurbiprofen, celecoxib
Data Source
AI summary
The present invention provides an inhalation-type pharmaceutical composition for arthritis and preparation method thereof, comprising a first gas and an atomized medicine. The first gas comprises hydrogen. The gas volume concentration of hydrogen in the inhalation-type pharmaceutical composition is between 2 to 96%. The atomized medicine is selected from a group comprising indomethacin, flurbiprofen, celecoxib, and any combination thereof. The inhalation-type pharmaceutical composition of the present invention can remove harmful radicals in the body of the patient through the use of hydrogen while also increases the absorption effect of the medicine for the patient by using an atomized medicine. At the same time, because the use of the small amount of the vaporized pharmaceutical liquid can indirectly reduce the side effects on the user.