Inhalation Pharmaceutical Composition with Hydrogen Gas Carrier
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Solution Overview
Problem
Current treatments for Alzheimer's disease, such as N-methyl-D-aspartate receptor antagonists and cholinesterase inhibitors, only alleviate symptoms and are associated with side effects, lacking a curative effect without adverse reactions.
Innovation Solution
An inhalation-type pharmaceutical composition combining hydrogen gas with atomized medications like rivastigmine hydrogen tartrate, donepezil hydrochloride, or memantine hydrochloride, where the hydrogen gas concentration can range from 2 to 96%, enhancing medication absorption and reducing harmful radicals in the body.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional medications (cholinesterase inhibitors or N-methyl-D-aspartate receptor antagonists) are used to treat Alzheimer's disease, then certain symptoms can be relieved and acetylcholine content increased, but side effects occur including nausea, headache, diarrhea, insomnia, pain, hallucination, or dizziness
Solution Approach 1:
The patent changes the physical state of medication delivery from oral solid form to inhaled atomized liquid form, and introduces hydrogen gas as a carrier medium. This parameter change in delivery method allows the medication to be absorbed through the respiratory system, bypassing gastrointestinal side effects while maintaining therapeutic efficacy through direct pulmonary absorption into the bloodstream and brain.
Solution Approach 2:
Hydrogen gas serves as an intermediary carrier that delivers the atomized medication deep into the respiratory system. The hydrogen bubbles generated by electrolysis act as a vehicle to transport the medicinal liquid atoms throughout the lungs, facilitating efficient drug delivery without direct contact with the gastrointestinal tract that causes side effects.
2Ease of operation
If oral medications are administered to Alzheimer's patients, then the medication can reach the brain to improve symptoms, but the treatment process is complex and requires precise dosing control
Solution Approach 1:
The system employs automatic electrolysis of water to generate hydrogen bubbles and atomization of the medicinal liquid through ultrasonic vibration. These self-regulating processes eliminate the need for manual dosing control, making the device easier to operate while the automated control systems manage the complexity internally. Patients simply need to inhale through the device without complex administration procedures.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The inhalation-type composition provides improved therapeutic effects for Alzheimer's disease with reduced side effects by utilizing hydrogen to increase medication absorption and neutralize harmful radicals, offering a convenient treatment option.
Implementation Method 1
utilizing hydrogen to increase medication absorption and neutralize harmful radicals
Implementation Method 2
enhancing medication absorption by using an atomized medicine
Implementation Method 3
the first gas is a gas mixture of hydrogen and oxygen generated from electrolyzing water
Data Source
AI summary
The present invention provides an inhalation-type pharmaceutical composition for Alzheimer's disease and preparation method thereof, comprising a first gas and an atomized medicine. The first gas comprises hydrogen. The gas volume concentration of hydrogen in the inhalation-type pharmaceutical composition is between 2 to 96%. The atomized medicine is selected from a group comprising rivastigmine hydrogen tartrate, donepezil hydrochloride, galantamine hydrobromide, memantine hydrochloride, and any combination thereof. The inhalation-type pharmaceutical composition of the present invention can provide the convenience of taking medicine and removing harmful radicals in the body of the patient through the use of hydrogen while also increases the absorption effect of the medicine for the patient by using an atomized medicine. At the same time, because the use of the small amount of the vaporized pharmaceutical liquid can indirectly reduce the side effects on the user.