Hydrogen Peroxide Mucosa Spray for Controlled Oxidation
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Solution Overview
Problem
Existing hydrogen peroxide-based nasal sprays cause oxidative damage to mucosa and are discomforting, failing to effectively cleanse and disinfect nasal cavities while delivering therapeutic compounds efficiently.
Innovation Solution
A hydrogen peroxide-based nasal spray with controlled redox reactions using aerosolized droplets <100 microns, combined with skin moisturizers and therapeutic compounds, forms a self-adhering coating that gradually oxidizes mucus, loosening it for removal and delivering compounds into mucosa within 3 minutes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If hydrogen peroxide is used to cleanse and disinfect nasal cavities, then disinfection effectiveness is improved, but oxidative damage to mucosa occurs
Solution Approach 1:
The patent introduces an intermediary substance (cream or ointment containing skin moisturizers and/or therapeutic compounds) that is applied to the nasal mucosa before hydrogen peroxide administration. This intermediary layer acts as a protective barrier that mitigates oxidative damage while allowing the hydrogen peroxide to effectively disinfect the nasal cavity, thus resolving the contradiction between disinfection effectiveness and mucosal protection
Solution Approach 2:
The patent applies a protective cream or ointment containing skin moisturizers and/or therapeutic compounds to the nasal mucosa before administering hydrogen peroxide. This prior application creates a cushioning protective layer that prevents direct contact between hydrogen peroxide and the mucosa, thereby preventing oxidative damage while maintaining disinfection effectiveness
2Reliability
If hydrogen peroxide is applied to remove infected mucus, then cleansing effectiveness is improved, but discomfort increases
Solution Approach 1:
The patent uses an intermediary cream or ointment containing skin moisturizers and/or therapeutic compounds as a protective barrier between the hydrogen peroxide and the nasal mucosa. This intermediary layer allows the hydrogen peroxide to effectively oxidize and remove infected mucus while simultaneously reducing discomfort and irritation, thus resolving the contradiction between cleansing effectiveness and user comfort
Solution Approach 2:
The patent modifies the parameters of the hydrogen peroxide solution by adjusting its concentration and pH level, and by combining it with skin moisturizers and/or therapeutic compounds in a cream or ointment formulation. These parameter changes enable the solution to effectively oxidize mucus while reducing the harsh effects and discomfort associated with its use
3Reliability
If conventional nasal wash methods are used, then cleansing capability is provided, but device complexity and ease of operation deteriorate
Solution Approach 1:
The patent extracts the essential cleansing function from complex nasal wash apparatus (such as Neti pots requiring sinks and water reservoirs) and incorporates it into a simple spray bottle system. The hydrogen peroxide-based solution is delivered through a straightforward spray mechanism that can be used anywhere, eliminating the need for complex equipment while maintaining effective cleansing capability
Solution Approach 2:
The patent employs a simple, inexpensive spray bottle system that can be easily discarded or replaced, eliminating the need for complex, reusable nasal wash apparatus. This disposable or easily replaceable system provides effective cleansing without requiring sinks, water reservoirs, or other complicated equipment, thus resolving the contradiction between cleansing capability and device complexity
4Reliability
If therapeutic compounds are delivered into nasal cavities, then treatment effectiveness is improved, but delivery efficiency deteriorates due to mucus barrier
Solution Approach 1:
The patent applies a cream or ointment containing skin moisturizers and/or therapeutic compounds to the nasal mucosa before administering hydrogen peroxide. This preliminary application creates a protective and permeable layer that facilitates the subsequent delivery of therapeutic compounds into the nasal cavity, overcoming the mucus barrier and improving delivery efficiency while maintaining treatment effectiveness
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The spray effectively protects mucosa from oxidative damage, provides therapeutic relief, and enhances drug delivery into nasal cavities, addressing discomfort and ensuring rapid cleansing and disinfection.
Implementation Method 1
A hydrogen peroxide-based spray works by redox reaction between the hydrogen peroxide and mucus or bodily fluids of mucosa
Implementation Method 2
loosens mucus from nasal cavities by oxidation of mucus therein
Implementation Method 3
forms a self-adhering coating that gradually oxidizes mucus
Implementation Method 4
A hydrogen peroxide-based nasal spray with controlled redox reactions using aerosolized droplets
Data Source
AI summary
The present invention is about a nasal spray or mucous membrane spray system for protection and treatment of mucosa, particularly nasal mucosa, from infections and allergies as well as its protection from oxidative damage caused by the use of a hydrogen peroxide-based nasal spray. A hydrogen peroxide-based spray works by redox reaction between the hydrogen peroxide and mucus or bodily fluids of mucosa; however it results in damage to mucosa in the long-term. The present invention mitigates this damage while providing therapeutic relief to the user suspected of being exposed to an infection or an allergy. The present invention enables cleansing, disinfection and treatment of nasal cavities by using a hydrogen peroxide-based nasal spray which loosens mucus from nasal cavities by oxidation of mucus therein and simultaneously enables enhanced delivery of one or more pharmaceutically acceptable compounds into nasal mucosa by the energy of redox reaction. The present invention minimizes the discomfort associated with the administration of hydrogen peroxide by enabling gradual oxidation of mucus or bodily fluids between 10-180 seconds. It protects mucosa form the harsh effects of hydrogen peroxides with skin moisturizers and disclosed therapeutic compounds which are penetrated into mucosa by the energy of redox reactions. The present invention enables treatment of localized mucosa as well as enhanced delivery of medicaments by the energy of redox reaction for use in the treatment of various medical conditions in less than 5 minutes.A directional spray bottle equipped with a metered pump is configured to deliver a pharmaceutical composition having 1.1-1,000 centipoise viscosity comprising hydrogen peroxide and one or more therapeutic compound in the form of aerosolized droplets <100 microns in sizes from a pharmaceutical composition consisting essentially of hydrogen peroxide 0.5%-3% w/w, a therapeutic compound and deionized water. When administered over mucosa, the aerosolized droplets form a substantially self-adhering reactive coating (2′) (FIG. 1a) therein <0.25 millimeter thick, thereby oxidizing mucus or bodily fluids therein between 10-180 seconds, thereby loosening mucus or bodily fluids from the mucosa, and simultaneously enables delivery of the therapeutic compound(s) and deionized water into mucosa by the energy of redox reaction between the hydrogen peroxide and mucus or bodily fluids.