Hydrogen Sulfide Sustained Releasing Dressing
Solution Overview
Problem
Current hydrogen sulfide donors, such as sodium hydrosulfide, release high concentrations of hydrogen sulfide gas quickly, leading to cytotoxicity and limiting their medical application for wound healing due to adverse reactions.
Innovation Solution
A hydrogen sulfide sustained releasing dressing comprising a hydrocolloid, surfactant, and sodium hydrosulfide, with specific weight ratios and additives like polysorbate and antioxidants, which controls the release rate of hydrogen sulfide to maintain concentrations below 1300 μM, preventing cytotoxicity and enhancing wound healing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If sodium hydrosulfide is used as hydrogen sulfide donor, then hydrogen sulfide gas is released, but the release is too fast causing high concentration cytotoxicity
Solution Approach 1:
The patent introduces a hydrocolloid matrix as an intermediary substance that mediates the release of hydrogen sulfide from sodium hydrosulfide. The hydrocolloid absorbs the sodium hydrosulfide and controls its interaction with water, thereby regulating the hydrogen sulfide release rate to prevent cytotoxicity while maintaining therapeutic efficacy.
Solution Approach 2:
The patent changes the physical and chemical parameters of the hydrogen sulfide delivery system by incorporating it into a hydrocolloid matrix with specific properties (viscosity, gel structure). This modifies the release kinetics from immediate/fast release to sustained/release over time, keeping concentration below toxic thresholds while delivering sufficient total dose.
2Productivity
If high concentration hydrogen sulfide is released quickly, then immediate effect is achieved, but adverse reactions such as cell apoptosis or inflammation occur
Solution Approach 1:
The patent applies beforehand cushioning by using the hydrocolloid matrix to pre-buffer the sodium hydrosulfide before it contacts water. The hydrocolloid structure acts as a cushion that gradually allows water penetration and controlled reaction, preventing sudden high concentration release and associated adverse reactions.
3Quantity of substance
If low concentration hydrogen sulfide is used for wound healing, then cytotoxicity is avoided, but the healing effect is insufficient
Solution Approach 1:
The patent implements continuity of useful action by designing a sustained release system that maintains low non-toxic hydrogen sulfide concentrations over an extended period. The hydrocolloid matrix continuously releases hydrogen sulfide at a controlled low concentration, ensuring cumulative therapeutic effect sufficient for wound healing without exceeding toxic thresholds at any moment.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The dressing effectively sustains the release of hydrogen sulfide over an extended period without causing cytotoxicity, improving chronic wound healing by maintaining optimal hydrogen sulfide concentrations within a safe range.
Implementation Method 1
the reaction that sulfide ion (HS−) from sodium hydrosulfide combines with hydrogen ion (H+) in water to release hydrogen sulfide gas
Implementation Method 2
A hydrogen sulfide sustained releasing dressing comprising a hydrocolloid, surfactant, and sodium hydrosulfide, with specific weight ratios and additives like polysorbate and antioxidants, which controls the release rate of hydrogen sulfide
Data Source
AI summary
The invention is to provide a hydrogen sulfide sustained releasing dressing and a manufacturing method thereof. The hydrogen sulfide sustained releasing dressing includes a hydrocolloid, a surfactant and sodium hydro sulfide. The manufacturing method includes (a) heating and stirring a hydrocolloid material; (b) adding a surfactant and sodium hydrosulfide into the hydrocolloid material; and (c) injecting the hydrocolloid material containing the surfactant and the sodium hydrosulfide into a mold for thermoforming a hydrogen sulfide sustained releasing dressing.