Molecular Hydrogen and Trehalose Ophthalmic Preparation
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Solution Overview
Problem
Oxidative stress plays a significant role in inflammatory and degenerative diseases of the cornea and retina, with existing treatments often failing to provide convincing effects and sometimes causing adverse side effects.
Innovation Solution
A pharmaceutical preparation combining molecular hydrogen (H2) with trehalose, an anti-inflammatory and anti-oxidative agent, to enhance the synergistic effects in treating inflammatory and degenerative diseases.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If high doses of antioxidants or anti-inflammatory medicaments are administered, then oxidative stress and inflammation are reduced, but serious adverse side effects occur and convincing therapeutic effects are not achieved
Solution Approach 1:
The patent changes the parameter of molecular hydrogen concentration to a specific range (0.1-10 mmol/L) and combines it with trehalose concentration (1-100 mmol/L) to achieve optimal therapeutic effect while minimizing side effects. This parameter optimization resolves the contradiction by finding the effective dose range that provides reliable therapeutic effects without adverse reactions.
Solution Approach 2:
The patent creates a composite pharmaceutical preparation combining molecular hydrogen with trehalose, leveraging the synergistic effects of both substances. Trehalose enhances the antioxidant and anti-inflammatory properties of molecular hydrogen, achieving more reliable and effective treatment outcomes compared to either substance alone, thereby resolving the reliability issue.
2Object-affected harmful factors
If conventional antioxidant or anti-inflammatory treatments are used, then some therapeutic effect is achieved, but the effects are not convincing and adverse side effects occur
Solution Approach 1:
The patent merges molecular hydrogen with trehalose in a single pharmaceutical preparation, creating a synergistic combination that enhances therapeutic effectiveness. The combination produces a greater than additive effect in reducing oxidative stress and promoting tissue healing, thereby achieving convincing therapeutic results while avoiding the limitations of conventional single-agent treatments.
3Object-affected harmful factors
If molecular hydrogen is used alone, then antioxidant effect is provided, but the effect is not sufficient for severe inflammatory and degenerative diseases
Solution Approach 1:
The patent introduces trehalose as an intermediary substance that enhances the therapeutic sufficiency of molecular hydrogen. Trehalose acts as a synergistic agent that amplifies the antioxidant and anti-inflammatory effects of molecular hydrogen, making the treatment reliable and sufficient for severe inflammatory and degenerative diseases of the cornea and retina.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination of molecular hydrogen and trehalose effectively reduces oxidative stress, inflammation, and cellular apoptosis, promoting rapid tissue regeneration and accelerated healing in the cornea and retina.
Implementation Method 1
Small molecules of molecular hydrogen H2 penetrate the damaged tissues and cells and quickly reach the nucleus
Implementation Method 2
In the nucleus, they decompose reactive oxy-radicals
Implementation Method 3
Trehalose suppressed proinflammatory cytokine induction. It was suggested that suppression of proinflammatory cytokines contributed strongly to reduced matrix metalloproteinase and xanthine oxidase expression in the UVB-irradiated corneal epithelium and to the decreased development of an antioxidant/pro-oxidant imbalance
Implementation Method 4
the anti-oxidative effects of molecular hydrogen H2 increase in synergic way in the presence of trehalose
Data Source
AI summary
A pharmaceutical preparation comprising molecular hydrogen H2 with increased anti-oxidative effect for the prevention and treatment of inflammatory and degenerative diseases.