Hydrogenated Lecithin Composition for Hyaluronic Acid Skin Penetration
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Solution Overview
Problem
Existing methods for applying hyaluronic acid to the skin result in retention on the surface due to the stratum corneum's barrier function, leading to insufficient moisture retention and decreased flexibility, and require complex preparation steps like ultracentrifugation.
Innovation Solution
A composition comprising hydrogenated lecithin, hyaluronic acid, and a dihydric alcohol, with a mass ratio of hyaluronic acid to hydrogenated lecithin between 9.0 and 90, enhancing the penetrability and flexibility of the stratum corneum without complex preparation steps.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If hyaluronic acid is applied to the skin, then moisturizing function is provided, but the stratum corneum barrier function prevents penetration into the skin
Solution Approach 1:
The patent uses a specific composition containing hydrogenated lecithin and dihydric alcohol as intermediary substances to facilitate the penetration of hyaluronic acid through the stratum corneum barrier. The hydrogenated lecithin acts as a mediator that temporarily disrupts the barrier function, allowing hyaluronic acid to penetrate while maintaining its moisturizing effect.
Solution Approach 2:
The patent changes the physical and chemical parameters of the hyaluronic acid delivery system by using a specific mass ratio composition (hyaluronic acid: hydrogenated lecithin: dihydric alcohol = 9.0-90:1-9.0:0.01-1.0). This parameter optimization enables the composition to penetrate the stratum corneum effectively while maintaining moisturizing function.
2Ease of operation
If hyaluronic acid is retained on the skin surface, then simple application is used, but sufficient moisture content in the stratum corneum is not maintained
Solution Approach 1:
The composition uses hydrogenated lecithin and dihydric alcohol as intermediary agents that enable hyaluronic acid to penetrate the stratum corneum barrier. This allows simple application methods to achieve deep penetration and effective moisture content maintenance in the stratum corneum, resolving the contradiction between ease of operation and reliability of moisture maintenance.
3Ease of manufacture
If hyaluronic acid is loaded on loading material or conjugated with another material, then penetrability is improved, but complicated preparation steps such as ultracentrifugation are required
Solution Approach 1:
The patent extracts and eliminates the need for complex nanoparticle preparation methods (ultracentrifugation, loading materials, conjugation). Instead, it uses a simple composition of hyaluronic acid, hydrogenated lecithin, and dihydric alcohol that can be prepared by straightforward mixing, achieving penetrability without complicated preparation steps.
Solution Approach 2:
The patent changes the formulation parameters to a specific mass ratio composition that inherently provides penetrability without requiring complex preparation. The optimized ratio of hyaluronic acid (9.0-90 parts), hydrogenated lecithin (1-9.0 parts), and dihydric alcohol (0.01-1.0 parts) creates a system that penetrates effectively through simple mixing.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition improves the penetrability of hyaluronic acid into the skin and enhances the flexibility of the stratum corneum, maintaining moisture retention and improving skin conditions.
Implementation Method 1
the composition capable of increasing penetrability of hyaluronic acid into the skin
Implementation Method 2
hyaluronic acid, which has a moisturizing function
Implementation Method 3
maintaining its flexibility, and maintaining favorable skin conditions, as long as the moisture content in the stratum corneum is maintained
Data Source
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AI summary
To provide a composition capable of increasing penetrability of hyaluronic acid into the skin, and of improving properties such as the flexibility of the stratum corneum, without requirement of complicated steps such as loading a hyaluronic acid component on a loading material. A composition of the present disclosure comprises hydrogenated lecithin, hyaluronic acid, and a dihydric alcohol, wherein the mass ratio of the hyaluronic acid to the hydrogenated lecithin is more than 9.0 and less than 90.