Hydrolyzed Clinoptilolite Fragments for GI Absorption
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Solution Overview
Problem
Current clinoptilolite formulations are not water-soluble and bio-absorbable, preventing them from effectively binding heavy metals in the gastrointestinal tract upon oral administration.
Innovation Solution
Development of water-soluble hydrolyzed clinoptilolite fragments through a hydrolysis reaction using phosphoric acid, allowing for absorption in the GI tract and systemic detoxification by binding heavy metals.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If clinoptilolite is administered as a water suspension, then it can be orally administered, but it is not absorbed in the GI tract and is simply eliminated
Solution Approach 1:
The patent applies parameter changes by modifying the physical and chemical state of clinoptilolite through hydrolysis treatment. This transforms the non-water-soluble clinoptilolite into water-soluble hydrolyzed clinoptilolite fragments, changing its solubility parameter to enable both oral administration and GI tract absorption simultaneously
Solution Approach 2:
The patent creates a composite formulation by combining hydrolyzed clinoptilolite fragments with water to form a water-soluble composition. This composite approach allows the clinoptilolite to maintain its heavy metal binding properties while gaining water solubility and bioabsorbability for effective GI tract delivery
2Reliability
If clinoptilolite is made water-soluble through hydrolysis, then it can be absorbed in the GI tract, but the processing complexity increases
Solution Approach 1:
The patent applies preliminary action by performing hydrolysis treatment on clinoptilolite before its biological application. This pre-processing step converts the raw clinoptilolite into water-soluble hydrolyzed fragments in advance, ensuring that the material is ready for absorption when administered, without requiring complex processing during the actual application
3Device complexity
If clinoptilolite is used in simple water suspension, then the formulation is simple, but it cannot bind heavy metals in vivo
Solution Approach 1:
The patent changes the solubility parameter of clinoptilolite through hydrolysis, transforming it from non-water-soluble to water-soluble. This parameter change enables the formulation to maintain simplicity as a water-based solution while simultaneously gaining the ability to bind heavy metals in vivo through the absorbed hydrolyzed fragments
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The water-soluble hydrolyzed clinoptilolite fragments can cross cellular membranes, providing systemic detoxification and binding heavy metals, with benefits including reduced inflammation and improved energy, focus, and memory.
Implementation Method 1
performing a hydrolysis reaction by hydrolyzing clinoptilolite with an acid
Implementation Method 2
the absorbed clinoptilolite retains the ability to bind various heavy metals
Data Source
AI summary
Methods are provided to make clinoptilolite into a water-soluble hydrolyzed form suitable for various administration routes, including oral administration. Absorption of water-soluble hydrolyzed clinoptilolite fragments can aid in detoxification by binding heavy metals and environmental toxins, can reduce reactive oxygen species and inflammation related to heavy metals and other/environmental toxins, resulting in an increase in energy, and/or in an increase in one or more of focus, concentration, and memory. Water-soluble hydrolyzed clinoptilolite fragments can be combined with one or more dietary supplements, including various vitamins and sleep aids.