Hydrophilic Core-Shell Fiber Membrane for Sustained Curcumin Release
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Solution Overview
Problem
Current wound dressings for diabetic wounds lack hydrophilicity and sustained release of curcumin, leading to frequent dressing changes, infection risk, and prolonged healing times due to burst drug release and poor exudate absorption.
Innovation Solution
A hydrophilic fiber membrane with a core-shell structure, where the core contains curcumin and a first spinnable polymer, and the shell contains polyethylene glycol and a second spinnable polymer, controlled via coaxial electrospinning to achieve sustained drug release and enhanced exudate absorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If hydrophilic materials are used to improve exudate absorption, then the dressing can absorb exudates effectively, but the drug is completely released within a few hours instead of achieving sustained release
Solution Approach 1:
The fiber is divided into a core region containing the drug (curcumin) and a shell region containing hydrophilic polymer. This segmentation allows the core to provide sustained drug release while the shell provides hydrophilicity for exudate absorption, resolving the contradiction between absorption capability and sustained release duration.
Solution Approach 2:
The invention uses a composite fiber structure combining hydrophobic polymer (for sustained release) and hydrophilic polymer (for exudate absorption) in a core-shell configuration. This composite material simultaneously achieves both exudate absorption and sustained drug release, eliminating the need to choose between these two functions.
2Reliability
If direct application of curcumin is used to treat wounds, then the curcumin provides antibacterial and healing effects, but the high local concentration produces toxic reactions
Solution Approach 1:
The hydrophilic polymer shell acts as an intermediary between the curcumin in the core and the wound surface. It controls the release of curcumin, preventing high local concentration and toxic reactions while maintaining the healing effects through sustained release.
Solution Approach 2:
The invention changes the release rate parameter of curcumin from rapid/burst release to sustained release by controlling the shell composition and thickness. This parameter change reduces local concentration peaks and eliminates toxic reactions while preserving therapeutic effectiveness.
3Device complexity
If hydrophobic medical gauze is used for wound dressing, then the dressing structure is simple, but it is difficult to absorb exudates and has poor biocompatibility
Solution Approach 1:
The fiber membrane has different properties in different regions: the core provides drug storage and sustained release, while the shell provides hydrophilicity for exudate absorption. This local quality differentiation allows a simple overall structure to achieve multiple functions including exudate absorption and biocompatibility.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The membrane provides sustained release of curcumin, preventing early burst release and improving wound healing by absorbing exudates effectively, reducing the need for frequent dressing changes and minimizing toxic reactions.
Implementation Method 1
the release rate of a drug in fibers is mainly determined by an intrusion rate of water
Implementation Method 2
the polyethylene glycol in the shell provides the fiber with hydrophilic properties, thus giving the fiber membrane a strong ability to absorb exudates
Implementation Method 3
conducting coaxial electrospinning on a core spinning solution and a shell spinning solution to obtain the hydrophilic fiber membrane with a sustained-release drug
Data Source
AI summary
The present disclosure provides a hydrophilic fiber membrane with a sustained-release drug, and belongs to the field of biological materials. The present disclosure provides a hydrophilic fiber membrane with a sustained-release drug, including a fiber with a core-shell structure, where a core of the fiber includes curcumin and a first spinnable polymer, and a shell of the fiber includes polyethylene glycol and a second spinnable polymer; and in the shell, the polyethylene glycol and the second spinnable polymer have a mass ratio of not greater than 1:12. In the present disclosure, the fiber membrane has a core-shell structure, the curcumin is provided in the core, and the shell prevents a rapid release of the curcumin in an early stage, thereby delaying a release rate of the curcumin to prevent the drug from forming a burst release in the early stage and causing toxic reactions.