Hydrophilic Monomers for High Protein Binding Capacity
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Solution Overview
Problem
Ion exchange monomers derived from vinyldimethylazlactone (VDM) and isocyanatoethylmethacrylate (IEM) exhibit reduced binding capacities when grafted as copolymers with conventional comonomers, necessitating the development of new monomers that minimize this reduction in binding capacity.
Innovation Solution
The introduction of hydrophilic monomers with multiple hydrogen bond donors and acceptors, represented by specific formulas, which form polymers that enhance interchain and intrachain hydrogen bonding interactions, are used to create high-protein binding capacity grafted copolymers when combined with isocyanatoethylmethacrylate-based ion exchange monomers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If ion exchange monomers (VDM or IEM) are grafted as copolymers with conventional comonomers, then polymer formation and processability are improved, but binding capacity for biological substances is reduced
Solution Approach 1:
The invention changes the chemical parameters of the comonomer by introducing specific functional groups (carboxylic acid, hydroxyl, amine, or combinations) at defined positions in the monomer structure. This allows optimization of both polymerization behavior and binding capacity through controlled molecular structure modification rather than using conventional comonomers.
Solution Approach 2:
The invention creates composite monomer structures that combine the ion exchange functionality of VDM/IEM with additional functional groups from the comonomer component. This composite approach at the molecular level enables simultaneous achievement of polymerization efficiency and enhanced or maintained binding capacity through multiple interaction mechanisms.
2Productivity
If ligand-functionalized membranes with high biomaterial binding capacities are developed, then purification efficiency is improved, but device complexity and manufacturing difficulty increase
Solution Approach 1:
The invention simplifies manufacturing by changing the monomer design parameters to include pre-formed functional groups that directly participate in binding. This eliminates the need for complex post-synthesis functionalization steps, reducing device complexity while maintaining high purification efficiency through inherent monomer structure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
These hydrophilic monomers maintain or minimize the reduction in binding capacity, resulting in polymers with high protein binding capacities, suitable for use in biopharmaceutical purifications and viral reduction applications.
Implementation Method 1
The introduction of hydrophilic monomers with multiple hydrogen bond donors and acceptors, represented by specific formulas, which form polymers that enhance interchain and intrachain hydrogen bonding interactions
Implementation Method 2
Ion exchange monomers derived from vinyldimethylazlactone (VDM) and isocyanatoethylmethacrylate (IEM) are known to provide grafted substrates with enhanced binding capacities for biological substances
Data Source
AI summary
Monomers, polymers formed from such monomers, and articles for biomaterial capture including such polymers, wherein the monomer is represented by the following general Formula (I): CH2=CR1-C(=O)-X-R2-Z-X3-NR3-C(=X2)-X1-R4, wherein: R1 is H or -CH3; R2 is a (hetero)hydrocarbylene; X is -O- or -NH-; X1 is -O-, -S-, -NH-, or a single bond; X2 is -O- or -S-; X3 is -O- or -NR5-; R4 is hydrogen, (hetero)hydrocarbyl, or -N(R3)2; each R3 and R5 is independently hydrogen or a (hetero)hydrocarbyl; and Z is -C(=O)- or -NH-C(=O)-.