Hydrous Adhesive Patch Using Water-Soluble Polymer for Dexmedetomidine
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Solution Overview
Problem
Conventional dexmedetomidine-containing patches often employ complex preparation structures and specific salts to achieve high absorbability, leading to increased skin irritation and rash.
Innovation Solution
A hydrous adhesive patch is developed using dexmedetomidine or its salt in combination with a water-soluble polymer, specifically a polyacrylic acid or carboxymethylcellulose, with a water content of 25-70% and a pH of 6-7, along with polyhydric alcohols and fatty acid esters to enhance transdermal absorbability while minimizing skin irritation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional patches use complex preparation structures or specific salts to achieve high absorbability, then transdermal absorbability is improved, but skin irritation and rash increase
Solution Approach 1:
The patent changes the chemical parameters of the adhesive base by selecting specific water-soluble polymers (polyacrylic acid or carboxymethylcellulose) with controlled molecular weights and degrees of neutralization, along with controlling water content (25-70 mass%) and pH (6-7), to achieve high transdermal absorbability without skin irritation
Solution Approach 2:
The patent uses a composite adhesive base composed of water-soluble polymer, water, and optional absorption enhancers (polyhydric alcohols, fatty acid esters) to create a synergistic system that provides both high drug delivery and skin compatibility
2Object-affected harmful factors
If conventional patches use simple structures to reduce skin irritation, then skin irritation is reduced, but transdermal absorbability decreases
Solution Approach 1:
The patent optimizes physical parameters including water content (25-70 mass%), pH (6-7), and polymer concentration (5-25 mass%) to maximize drug permeation while maintaining skin compatibility, achieving high absorbability without complex structures
Solution Approach 2:
The hydrous adhesive base with high water content creates a porous, hydrated matrix that facilitates drug diffusion and enhances transdermal absorbability through the stratum corneum without requiring complex multi-layer structures
Data Source
AI summary
Provided is a patch providing sufficiently high absorbability of dexmedetomidine and less skin irritation.Hydrous adhesive patch comprising dexmedetomidine or a salt thereof and a water-soluble polymer.