Hydroxy Aliphatic Phenyl Ether Derivatives for Neuroplasticity

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current treatments for neurodegenerative diseases and cognitive disorders, such as Alzheimer's and Parkinson's, have limited effectiveness in promoting neuroplasticity and improving learning and memory, necessitating the development of new drugs that can enhance these processes.

Innovation Solution

Development of hydroxy aliphatic substituted phenyl aminoalkyl ether compounds that increase the phosphorylation of ERK and Akt kinases, inhibit serotonin and norepinephrine reuptake, and have pleiotropic effects, potentially treating cognitive deficits, depression, and pain.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If current treatments for neurodegenerative diseases are used, then existing therapeutic options are maintained, but effectiveness in promoting neuroplasticity and improving learning and memory is limited

Engineering Contradiction:

Improveeffectiveness in promoting neuroplasticityVSAvoidability to improve learning and memory

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent applies parameter changes by modifying the chemical structure of phenylaminoalkyl ether compounds to optimize their pharmacological properties. Specifically, the compounds are designed with specific hydroxy aliphatic substitutions and aminoalkyl groups that enhance their ability to promote neuroplasticity and improve cognitive function, thereby resolving the contradiction between maintaining treatment reliability and improving adaptability for learning and memory enhancement

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs composite materials by creating compounds with multiple functional groups that work synergistically. The phenylaminoalkyl ether core structure is combined with hydroxy aliphatic substitutions and various aminoalkyl groups to produce a multifunctional molecule that simultaneously promotes neuroplasticity, enhances learning and memory, and provides additional therapeutic benefits, thus addressing both reliability and adaptability requirements

Inventive Principle:

Principle #40Composite materials

2Reliability

If new drugs are developed to enhance neuroplasticity, then learning and memory improvement is enhanced, but drug complexity increases

Engineering Contradiction:

Improveneuroplasticity promotionVSAvoiddrug molecular structure

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies segmentation by dividing the drug molecule into distinct functional modules: a phenylaminoalkyl ether core structure, hydroxy aliphatic substitution groups, and aminoalkyl side chains. This modular design allows each segment to contribute specific pharmacological activities while maintaining overall molecular manageability and facilitating structure-activity relationship studies

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patent implements local quality by introducing specific functional groups at particular positions on the molecular structure. The hydroxy aliphatic substitutions and aminoalkyl groups are placed at specific locations to optimize their interaction with neural targets, ensuring that each part of the molecule contributes to neuroplasticity promotion without unnecessary complexity

Inventive Principle:

Principle #3Local quality

3Adaptability or versatility

If compounds with multiple pharmacological effects are used, then treatment versatility is improved, but manufacturing complexity increases

Engineering Contradiction:

Improvepleiotropic effectsVSAvoidsynthesis complexity

Core Design Contradiction:

Adaptability or versatilityVSEase of manufacture

Solution Approach 1:

The patent applies universality by designing a single compound platform that can exhibit multiple pharmacological effects through its structural features. The phenylaminoalkyl ether core with hydroxy aliphatic substitutions and aminoalkyl groups can simultaneously engage with multiple neural targets, providing pleiotropic effects including neuroplasticity promotion, learning and memory enhancement, and additional therapeutic benefits from a single molecule

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent uses extraction by isolating and optimizing the key functional elements (phenylaminoalkyl ether core, hydroxy aliphatic groups, aminoalkyl substitutions) that are responsible for the desired pharmacological effects. By focusing on these essential components and removing unnecessary structural elements, the patent simplifies the manufacturing process while maintaining the compound's versatile therapeutic potential

Inventive Principle:

Principle #2Taking out (Extraction)

Data Source

PatentUS9980928B2Hydroxy aliphatic substituted phenyl aminoalkyl ether derivatives

Publication Date: 2018.05.29 PROUS INST FOR BIOMEDICAL RES

AI summary

Hydroxy aliphatic substituted phenyl aminoalkyl ether compounds of formula (I), and compositions thereof, are useful as a medicament in the treatment of nervous system diseases and/or the treatment of developmental, behavioral and/or mental disorders associated with cognitive deficits.