Hydroxyapatite Oral Composition for Dentinal Tubule Sealing

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Solution Overview

Problem

Conventional methods for addressing tooth hypersensitivity, such as using fluoride or aluminum salts to seal dentinal tubules, are insufficient in terms of adhesion properties and persistence of effect.

Innovation Solution

An oral composition containing hydroxyapatite particles with specific X-ray diffraction peak intensity ratios and properties, which effectively seal and adhere to dentinal tubules, reducing hypersensitivity.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If fluoride or aluminum salts are used to seal dentinal tubules, then hypersensitivity can be addressed, but adhesion properties and persistence of effect are insufficient

Engineering Contradiction:

Improveadhesion propertiesVSAvoidpersistence of effect

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent changes the chemical composition parameters of the sealing particles by using hydroxyapatite with specific Ca/P molar ratio (1.67 or less) and controlled crystallinity, which improves both adhesion properties and persistence of effect compared to conventional fluoride or aluminum salts

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs composite particles consisting of hydroxyapatite core coated with fluoride-containing substance, combining the sealing capability of hydroxyapatite with the remineralization effect of fluoride to achieve superior adhesion and long-lasting effect

Inventive Principle:

Principle #40Composite materials

2Reliability

If conventional sealing methods are used, then dentinal tubules can be sealed, but the sealing effectiveness and durability are insufficient

Engineering Contradiction:

Improvesealing effectivenessVSAvoiddurability

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent optimizes the crystallinity parameter of hydroxyapatite particles (30-70%) and their size distribution (D10-D90 ratio of 0.2-2.0), which significantly enhances sealing effectiveness and durability by improving particle penetration and adhesion to dentinal tubules

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates local quality enhancement by coating hydroxyapatite particles with fluoride-containing substances, concentrating the sealing and remineralization effects at the dentinal tubule interface where they are most needed

Inventive Principle:

Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The oral composition with hydroxyapatite particles provides excellent adhesion and sealing of dentinal tubules, effectively reducing tooth hypersensitivity and improving the persistence of the treatment effect.

Implementation Method 1

specific hydroxyapatite particles... have properties to seal dentinal tubules and excellent adhesion properties in dentinal tubules

Methodology Applied

Scientific EffectAdhesion: Adhesive

Implementation Method 2

the hydroxyapatite particles have a ratio of a diffraction peak intensity around 2θ=32° to a diffraction peak intensity around 2θ=26° of 0.8 to 1.6 in an x-ray powder diffraction pattern as measured with a CuKα characteristic X-ray

Methodology Applied

Scientific EffectX-ray diffraction: X-Ray

Data Source

PatentUS11759405B2Composition for oral cavity

Publication Date: 2023.09.19 SUNSTAR SUISSE SA

AI summary

Provided is an oral composition containing particles that have properties to seal dentinal tubules and excellent adhesion properties in dentinal tubules. Specifically, provided is an oral composition containing hydroxyapatite particles, wherein the hydroxyapatite particles have a ratio of a diffraction peak intensity around 2θ=32° to a diffraction peak intensity around 2θ=26° of 0.8 to 1.6 in an x-ray powder diffraction pattern as measured with CuKα characteristic X-rays.