Hydroxybenzoic Acid Amides Masking Bitter Peptides

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Solution Overview

Problem

Current methods for masking unpleasant tastes in food and beverages, such as bitter or astringent flavors, are limited in effectiveness and often impact the bioavailability of desirable ingredients or introduce unwanted taste profiles, especially when used in low concentrations.

Innovation Solution

The use of hydroxybenzoic acid amides and their salts, specifically compounds like 2,4-dihydroxy-N-[(4-hydroxy-3-methoxyphenyl)methyl]benzamide, to effectively mask bitter, astringent, and metallic tastes in low concentrations without altering the overall taste experience, particularly when combined with specific peptides and amino acid mixtures.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If conventional bitter masking substances are used, then bitter taste is suppressed, but they introduce unwanted taste profiles or affect bioavailability

Engineering Contradiction:
Improvebitter tasteVSAvoidunwanted taste profiles
Core Design Contradiction:
Object-affected harmful factorsVSObject-generated harmful factors

Solution Approach 1:

The patent employs specific masking substances (such as cyclodextrins, polyamino acids, and plant extracts) as intermediary compounds that selectively bind to bitter-tasting peptides and amino acids without introducing unwanted tastes. These intermediaries act as mediators between the bitter substances and the consumer's taste receptors, suppressing bitterness while preserving the natural taste profile of the food or beverage.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention utilizes parameter changes by adjusting the molecular weight, concentration, and chemical structure of masking substances to optimize bitter suppression effectiveness. For example, polyamino acids with molecular weights of at least 500 Da are specified, and cyclodextrin derivatives with specific hydroxypropyl substitution levels are used to enhance binding affinity to bitter compounds while maintaining safety and taste acceptability.

Inventive Principle:
Principle #35Parameter changes

2Object-affected harmful factors

If masking substances are used in high concentrations, then bitter taste is effectively suppressed, but the substances themselves introduce new taste qualities

Engineering Contradiction:
Improvebitter taste suppressionVSAvoidnew taste qualities
Core Design Contradiction:
Object-affected harmful factorsVSObject-generated harmful factors

Solution Approach 1:

The patent optimizes the concentration parameters of masking substances to achieve effective bitter suppression at the lowest possible doses. Specific concentration ranges are provided for different masking agents (e.g., cyclodextrins at 0.01-10 g/L, polyamino acids at 0.001-1 g/L) to suppress bitterness without introducing detectable taste changes from the masking substances themselves.

Inventive Principle:
Principle #35Parameter changes

3Object-affected harmful factors

If specific masking agents are used to target certain peptides, then bitter taste is reduced, but the method becomes highly specific and less versatile

Engineering Contradiction:
Improvebitter taste of specific peptidesVSAvoidmasking method applicability
Core Design Contradiction:
Object-affected harmful factorsVSAdaptability or versatility

Solution Approach 1:

The patent employs masking substances with broad-spectrum activity that can suppress bitter tastes from multiple different peptide and amino acid sources simultaneously. Cyclodextrins, polyamino acids, and certain plant extracts are shown to effectively mask bitterness from casein phosphopeptides, whey peptides, soy peptides, and other protein hydrolysates, providing a universal masking solution applicable to diverse food and beverage products.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Data Source

PatentEP3355719B1Use of some hydroxybenzoic acid amides for masking unpleasant taste
Publication Date: 2020.08.19 SYMRISE GMBH & CO KG
  • EP3355719B1 patent drawing
  • EP3355719B1 patent drawing
  • EP3355719B1 patent drawing

AI summary

The present invention relates primarily to the use of certain hydroxybenzoic acid amides or the salts or mixtures thereof for masking an unpleasant taste impression, preferably of a bitter, adstringent, dusty, dry, floury, rancid, metallic and/or cardboard taste or aftertaste, of one or more unpleasant-tasting peptides or of certain amino acid mixtures. The invention further relates to a corresponding method for masking unpleasant taste impressions and to novel preparations.