3-Hydroxybutyrate Compounds for Preventing Athlete Overtraining
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Solution Overview
Problem
Current treatments for overtraining syndrome are inadequate, and there is a need for effective methods to prevent and treat the systemic inflammatory process and associated symptoms such as decreased performance, muscle damage, and hormonal dysregulation.
Innovation Solution
Utilizing exogenous ketone body precursors like (R)-3-hydroxybutyrate, its esters, and oligomers to provide a source of ketone bodies, which can be administered orally to enhance exercise performance, reduce muscle damage, and stabilize hormonal levels.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If increased training loads are used to improve performance, then athletic performance increases, but overtraining syndrome develops causing performance decline and systemic inflammation
Solution Approach 1:
The patent applies preliminary action by administering ketone body precursors before strenuous exercise to prevent overtraining syndrome. The compounds are given in advance to establish protective metabolic conditions, allowing athletes to withstand increased training loads without developing systemic inflammation and performance decline
2Reliability
If rest periods are increased to prevent overtraining, then recovery is improved, but training volume and performance gains are reduced
Solution Approach 1:
The patent changes the metabolic parameter by introducing exogenous ketone body precursors, which alter the body's fuel utilization and reduce oxidative stress. This metabolic shift allows for reduced rest periods while maintaining recovery capacity, enabling higher training volumes without compromising performance stability
3Quantity of substance
If traditional ketogenic diets are used to achieve ketosis, then ketone levels increase, but carbohydrate intake is severely limited reducing exercise performance
Solution Approach 1:
The patent extracts the beneficial ketone body precursor (R)-3-hydroxybutyrate from the context of restrictive ketogenic diets. By providing the ketone precursor directly as a supplement rather than through dietary restriction, the invention achieves elevated ketone levels while allowing normal carbohydrate intake, thus maintaining exercise energy availability
Data Source
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AI summary
The present invention provides a compound for use in preventing or treating overtraining in a subject, wherein the compound is selected from (i) (R)-3-hydroxybutyrate; (ii) an ester of (R)-3-hydroxybutyrate; and (iii) an oligomer obtainable by oligomerising(R)-3-hydroxybutyrate moieties; or a pharmaceutically acceptable salt or solvate thereof.