Hydroxylated Urea Compounds for Skin Aging
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods fail to effectively address the signs of aging in skin and mucous membranes, including wrinkles, thinning of the epidermis, and dryness, due to disrupted epidermal proliferation and differentiation, and deterioration of the proteasome system with age.
Innovation Solution
Administration of hydroxylated urea compounds, formulated into a physiologically acceptable medium, to stimulate proteases in the skin and mucous membranes, enhancing proteolytic activities and promoting the degradation of oxidized proteins and maturation of the horny envelope.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional methods are used to address skin aging, then the skin barrier function is maintained, but signs of aging such as wrinkles and fine lines persist due to disrupted epidermal proliferation and differentiation
Solution Approach 1:
The patent applies parameter changes by modifying the chemical structure of urea compounds to introduce hydroxyl groups at specific positions (R1-R4 radicals), which changes the biochemical parameters of the molecule to enable protease stimulation activity while maintaining skin compatibility
Solution Approach 2:
The hydroxylated urea compounds act as intermediary substances that stimulate protease enzymes, which in turn degrade oxidized proteins and facilitate epidermal cell turnover, thereby addressing aging signs without directly damaging the skin barrier
2Productivity
If protease activities are stimulated to compensate for deterioration with age, then oxidized proteins are degraded, but uncontrolled proteolysis may affect skin health
Solution Approach 1:
The patent applies local quality by positioning hydroxyl groups at specific locations (R1-R4) on the urea molecule, which creates localized chemical reactivity that selectively stimulates proteases in the stratum corneum while maintaining overall skin safety
Solution Approach 2:
The urea compounds utilize the skin's own protease enzyme system to achieve the desired effect, allowing the skin to self-cleanse oxidized proteins through stimulated proteolysis rather than requiring external intervention that could cause damage
3Productivity
If epidermal proliferation is stimulated to compensate for aging, then skin renewal is improved, but disruption of differentiation may occur
Solution Approach 1:
The patent applies continuity of useful action by providing sustained stimulation of protease activity through repeated application of hydroxylated urea compounds, which continuously promotes epidermal cell turnover and renewal while maintaining stable differentiation through controlled, gradual changes
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The hydroxylated urea compounds effectively stimulate proteolytic enzymes, improving skin and mucous membrane health by reducing signs of aging, such as wrinkles and dryness, and addressing age-related protein accumulation.
Implementation Method 1
stimulate the activities in order to make up this deterioration... stimulating the protease activities for degradation of this protein... enhancing proteolytic activities and promoting the degradation of oxidized proteins
Implementation Method 2
the maturing of the HE (horny envelope), which can be detrimentally affected with age, is under the control of transglutaminase activities, themselves activated by proteolysis
Data Source
AI summary
Signs of aging of the skin and/or mucous membranes are prevented and/or reduced, and the activity of the proteolytic enzymes of the stratum corneum are stimulated as well, by administering to an individual in need of such treatment, a cosmetic/pharmaceutical composition which comprises a thus effective amount of at least one hydroxylated urea compound having the following formula (I):in which:the radicals R1, R2, R3 and R4, which may be identical or different, are each a hydrogen atom, a C1-C4 alkyl radical or a C2-C6 hydroxyalkyl radical which can contain from 1 to 5 hydroxyl groups, wherein at least one of the R1 to R4 radicals represents a hydroxyalkyl radical, or salt, solvate or isomer thereof, formulated into a physiologically acceptable medium therefor.