Hydroxypropyl Starch IgA Promoter for Mucosal Immunity
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Solution Overview
Problem
Current IgA production promoters do not effectively utilize modified starches like hydroxypropyl starch to enhance IgA production in mammals, particularly for preventing infections and allergic reactions by blocking pathogenic microorganisms and allergens in the alimentary tract.
Innovation Solution
An IgA production promoter comprising hydroxypropyl starch as an effective ingredient, which is orally administered, promoting IgA production in the small intestine by inhibiting the binding of pathogenic microorganisms and allergens, with a degree of substitution (DS) of 0.1 or more, allowing safe and continuous ingestion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional IgA production promoters (peptides, bacterial cells, mushroom components) are used, then IgA production is promoted, but the complexity of the composition and manufacturing process increases
Solution Approach 1:
The patent replaces complex biological substances (peptides, bacterial cells, mushroom components) with a simple, stable, and inexpensive modified starch that can be mass-produced and stored without special conditions. This starch derivative serves as a durable alternative to perishable biological promoters.
Solution Approach 2:
The patent modifies the chemical structure of starch by introducing hydroxypropyl groups and phosphate groups, changing its physical and chemical parameters to create a new substance with IgA-promoting activity. This chemical modification transforms an ordinary carbohydrate into a functional immunomodulator.
2Reliability
If complex biological substances are used as IgA promoters, then IgA production is enhanced, but the ease of manufacture and safety profile deteriorates
Solution Approach 1:
The patent replaces complex biological substances (peptides, bacterial cells, mushroom components) with a simple, stable, and inexpensive modified starch that can be mass-produced and stored without special conditions. This starch derivative serves as a durable alternative to perishable biological promoters.
Solution Approach 2:
The patent replaces biological systems (bacterial cells, mushroom components) with a chemically modified carbohydrate structure. This substitution eliminates the need for complex biological cultivation, extraction, and purification processes, allowing for simpler chemical manufacturing.
3Reliability
If modified starch with high degree of substitution is used, then IgA production is promoted, but the stability and safety of the composition may be compromised
Solution Approach 1:
The patent optimizes the degree of substitution parameters to achieve the optimal balance between IgA-promoting activity and compositional stability. By controlling the extent of hydroxypropylation and phosphorylation, the patent creates a modified starch that is both effective and stable.
Data Source
AI summary
To provide an IgA production promoter capable of being easily ingested safely and continually, for example orally and capable of preventing infection by inhibiting the binding of pathogenic microorganisms to alimentary canal mucosa and preventing an allergic reaction by blocking the passage of allergen materials such as pollen and house dust through the wall of the alimentary tract. The present invention consists of an IgA production promoter comprising hydroxypropyl starch as an effective ingredient. The IgA production promoter of the present invention can be safely and continually ingested because the effective ingredient thereof is hydroxypropyl starch used in food and the like, and can prevent infection by inhibiting the binding of pathogenic microorganisms to alimentary canal mucosa and prevent an allergic reaction by blocking the passage of allergen materials such as pollen and house dust through the wall of the alimentary tract.