8-Hydroxyquinoline Derivatives for Multi-Type HPV Therapy

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Solution Overview

Problem

Current prophylactic vaccines for human papillomavirus (HPV) infections have no significant therapeutic effect, and there is a need for effective drugs that can target multiple types of HPV to treat associated diseases, including malignant tumors.

Innovation Solution

The use of an 8-hydroxyquinoline derivative, its pharmaceutically acceptable salts, crystal forms, solvates, isotope derivatives, or prodrugs in the preparation of antiviral drugs, particularly anti-HPV drugs, with specific structural variations in R groups and substituents.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If prophylactic vaccines are used for HPV infection, then prevention of multiple HPV types is improved, but therapeutic effect on infected patients is insufficient

Engineering Contradiction:

Improveprevention effectivenessVSAvoidtherapeutic applicability

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The invention segments the functional requirements by developing separate solutions: prophylactic vaccines for prevention and novel 8-hydroxyquinoline derivative compounds for therapy. This allows each solution to be optimized for its specific purpose without compromise

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The 8-hydroxyquinoline derivative compounds are designed with broad-spectrum activity against multiple HPV types (including but not limited to HPV 6, 11, 16, 18), enabling a single therapeutic agent to address diverse infections, thus providing universal therapeutic applicability

Inventive Principle:

Principle #6Universality (Multi-functionality)

2Adaptability or versatility

If existing antiviral drugs are used, then some HPV types may be targeted, but effective drugs targeting multiple HPV types are lacking

Engineering Contradiction:

Improvemulti-HPV type coverageVSAvoidtherapeutic efficacy

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The 8-hydroxyquinoline derivative compounds are designed with broad-spectrum activity against multiple HPV types through systematic structure-activity relationship studies, enabling a single therapeutic agent to address diverse infections with proven efficacy

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The invention systematically varies structural parameters (R1-R6 substituents) of the 8-hydroxyquinoline core to optimize both the breadth of HPV type coverage and the therapeutic efficacy, achieving multiple HPV types targeting with reliable effectiveness

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentEP4623914A1Use of 8-hydroxyquinoline derivative

Publication Date: 2025.10.01 JIANGSU YAHONG MEDITECH CO LTD

AI summary

The present invention relates to use of a 8-hydroxyquinoline derivative, particularly, to use of a 8-hydroxyquinoline derivative represented by general formula (I), a pharmaceutically acceptable salt thereof, a crystal form thereof, a solvate thereof, an isotope derivative thereof, or a prodrug thereof in the preparation of an antiviral drug, and particularly, to use thereof in the preparation of an anti-human papillomavirus drug. The definition of each group in the general formula (I) is the same as that in the description.