Hydroxysafflor Yellow A Sodium Purification and Stability
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Conventional hydroxysafflor yellow A products have insufficient purity and stability, leading to decreased medicinal effectiveness and safety concerns due to high impurity content and inconsistent quality, which restricts their clinical application for treating blood circulation disorders.
Innovation Solution
A hydroxysafflor yellow A sodium compound is developed through a process involving extraction, sodium salt transformation, separation, and purification using specific resins and chromatography techniques, resulting in a product with improved purity and stability, ensuring safer and more effective treatment of coronary heart disease and angina pectoris.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional extraction and purification methods are used for hydroxysafflor yellow A, then the production process is simpler, but the purity is insufficient (impurity content above 10%) and stability decreases after long-time storage
Solution Approach 1:
The purification process is divided into multiple sequential steps using different resin types: first macroporous resin for initial purification, then ion-exchange resin for further purification, and finally gel filtration resin for final polishing. Each step targets specific impurities and progressively increases purity to above 98%, resolving the contradiction between purity and process complexity by breaking down the complex purification task into manageable segments.
Solution Approach 2:
The patent transforms hydroxysafflor yellow A into its sodium salt form (hydroxysafflor yellow A sodium), changing the chemical parameter from acid form to salt form. This parameter change significantly improves stability for long-time storage while maintaining high purity, directly addressing the contradiction between purity and stability.
2Stability of the object's composition
If conventional hydroxysafflor yellow A products are used, then the production cost is lower, but the stability is insufficient and medicinal effect decreases after long-time storage
Solution Approach 1:
The patent converts hydroxysafflor yellow A from its acid form to sodium salt form through neutralization with sodium hydroxide. This parameter change from acid to salt form fundamentally improves storage stability and prevents degradation during long-time storage, ensuring consistent medicinal effect. The sodium salt form is more stable and has better solubility, directly resolving the contradiction between stability and medicinal effect consistency.
Solution Approach 2:
The final product combines high purity hydroxysafflor yellow A sodium with well-defined chemical structure and properties. This composite approach ensures both stability during storage and reliable medicinal effect, as the purified sodium salt form maintains consistent pharmacological activity while resisting degradation.
3Productivity
If conventional extraction methods are used, then the turnover rate is above 20% with content above 80%, but the impurity content remains above 10% and quality is not completely controllable
Solution Approach 1:
The patent implements a multi-stage purification process that segments the impurity removal task: macroporous resin removes bulk impurities while maintaining high turnover, ion-exchange resin removes charged impurities, and gel filtration resin performs final polishing. This segmented approach achieves purity above 98% while maintaining reasonable productivity, resolving the contradiction between turnover rate and purity.
Solution Approach 2:
The patent uses three different resin materials as intermediary substances to facilitate purification at each stage. These intermediaries (macroporous resin, ion-exchange resin, gel filtration resin) selectively bind different types of impurities, enabling high purity extraction while maintaining efficient turnover rate through the coordinated action of multiple intermediaries.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The hydroxysafflor yellow A sodium compound achieves a purity of above 98.5%, enhancing safety and controllability, and demonstrates better stability and effectiveness in preventing platelet aggregation and treating cardiovascular disorders compared to conventional hydroxysafflor yellow A.
Implementation Method 1
separating the water extract through a macroporous resin column, obtaining a crude product of the safflor yellow
Implementation Method 2
separating the crude product through a dextran gel column
Implementation Method 3
filtering with an ultrafiltration membrane
Data Source
Figure 1
Figure 2
Figure 3
AI summary
A hydroxysafflor yellow A sodium compound as shown in a formula (I) and preparation as well as medicinal application thereof are provided. According to the present invention, the safflower is utilized as a raw material. A monomer pharmaceutical compound, the hydroxysafflor yellow A sodium, is obtained by sufficient processes, and a purity thereof is surely above 98.5%. Therefore, the hydroxysafflor yellow A sodium is a monomer compound, which is safer, more effective, more stable and more controllable than hydroxysafflor yellow A, for treating blood circulation disorders such as platelet aggregation, coronary heart disease, angina pectoris and acute cerebral ischemia. Furthermore, the hydroxysafflor yellow A sodium has sufficient solubility and human tolerance.