Hyperbranched Copolymer Compositions for Reduced Antimicrobial Use
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Solution Overview
Problem
Existing cosmetic compositions face challenges in maintaining antimicrobial properties while reducing the use of antimicrobial agents to address public health and regulatory concerns, necessitating a composition with enhanced stability and shelf life.
Innovation Solution
A composition comprising a hyperbranched copolymer of dodecenyl succinic acid anhydride, diisopropanol amine, and bis-dimethylaminopropyl amine, with terminal groups and a molecular weight of 1200 to 4000 g/mol, synergistically enhances the antimicrobial action of 1,3-propanediol and/or N-hydroxyoctanamide, providing a synergistic effect that maintains antimicrobial properties with reduced agent use.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If antimicrobial agents are used in cosmetic compositions to prevent microbial growth and extend shelf life, then the stability and shelf life of the composition are improved, but the use of antimicrobial agents increases which raises public health and regulatory concerns
Solution Approach 1:
The invention combines a hyperbranched copolymer with 1,3-propanediol and/or N-hydroxyoctanamide to create a composite antimicrobial system. The hyperbranched copolymer (with specific monomers including dodecenyl succinic acid anhydride, diisopropanol amine, and bis-dimethylaminopropyl amine) works synergistically with the antimicrobial agents to enhance effectiveness while allowing reduced quantities of the antimicrobial components.
Solution Approach 2:
The invention changes the molecular parameters of the copolymer system by using a hyperbranched structure with controlled molecular weight (1200-4000 g/mol) and specific terminal groups. This parameter optimization enables the copolymer to enhance antimicrobial activity, allowing the formulation to maintain stability with lower amounts of traditional antimicrobial agents.
2Object-affected harmful factors
If the use of antimicrobial agents is reduced to address public health concerns, then public health and regulatory compliance are improved, but the stability and shelf life of the composition deteriorate
Solution Approach 1:
The hyperbranched copolymer acts as an intermediary or adjuvant that enhances the antimicrobial activity of reduced quantities of 1,3-propanediol and/or N-hydroxyoctanamide. The copolymer's specific structure with terminal groups facilitates this synergistic interaction, allowing the system to maintain protective antimicrobial effectiveness even at lower agent concentrations.
Solution Approach 2:
By optimizing the molecular weight range (1200-4000 g/mol) and incorporating specific monomers with terminal groups in the hyperbranched copolymer, the invention changes the physical-chemical parameters to maximize the adjuvant effect, enabling reduced antimicrobial agent usage while maintaining stability.
3Duration of action of stationary object
If traditional antimicrobial formulations are used to ensure stability, then shelf life is maintained, but the quantity of antimicrobial agents increases which creates regulatory and public health issues
Solution Approach 1:
The formulation uses a composite system where the hyperbranched copolymer (with precisely controlled composition including dodecenyl succinic acid anhydride, diisopropanol amine, and bis-dimethylaminopropyl amine) combines with 1,3-propanediol and/or N-hydroxyoctanamide to achieve synergistic antimicrobial protection, extending shelf life with reduced agent quantities.
Solution Approach 2:
The invention optimizes the molecular parameters of the copolymer system, specifically controlling molecular weight (1200-4000 g/mol) and terminal group composition, to enhance the efficiency of the antimicrobial system, allowing extended shelf life with lower antimicrobial agent content.
Data Source
AI summary
The present invention relates to a composition comprising a specific hyperbranched copolymer (HBC) of the monomers dodecenyl succinic acid anhydride, diisopropanol amine and bis-dimethylaminopropyl amine and the compound 1,3-propandiol and/or N-hydroxyoctanamide. It has been found that said hyperbranched copolymer synergistically enhances the antimicrobial action of a 1,3-propanediol and/or N-hydroxy-octanamide.