Hyperbranched Dextrin Topicals for Skin Irritation Reduction
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
There is a need for new agents, particularly of natural or plant origin, capable of preventing or effectively treating symptoms of skin or mucous membrane inflammation such as redness, heat, swelling, and pain, as well as reducing the irritant effects of ingredients in cosmetic and dermatological compositions.
Innovation Solution
Hyperbranched and hydrogenated dextrins are used topically to decrease biomarkers associated with inflammation (IL-1α, IL-1β, RANTES, and VEGF) and maintain skin integrity, reducing symptoms like redness, heat, and swelling, and minimizing irritant effects of cosmetic ingredients.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If conventional ingredients are used in cosmetic compositions, then the compositions can provide desired cosmetic effects, but they may cause skin or mucous membrane inflammation and irritation
Solution Approach 1:
The patent introduces hyperbranched dextrins as intermediary substances that mediate between cosmetic ingredients and skin/mucous membranes. These dextrins act as protective agents that prevent direct harmful interactions while allowing the cosmetic compositions to maintain their desired functions, thus resolving the contradiction between effectiveness and irritation
Solution Approach 2:
The patent modifies the chemical structure of dextrins by creating hyperbranched configurations with specific molecular weight ranges (1000-3500 g/mol) and branching degrees (5-40%). These parameter changes transform ordinary dextrins into effective anti-inflammatory agents that can prevent skin and mucous membrane irritation while maintaining cosmetic composition functionality
2Object-generated harmful factors
If irritant ingredients are used to achieve desired cosmetic effects, then the cosmetic composition can be effective, but it causes irritation and inflammation of skin or mucous membranes
Solution Approach 1:
The patent converts the potentially harmful interaction between irritant ingredients and skin into a beneficial protective mechanism. Hyperbranched dextrins are applied to create a protective barrier that prevents irritant ingredients from causing damage, transforming the harmful effect into a controlled and beneficial protective action
Solution Approach 2:
The patent applies hyperbranched dextrins before the introduction of irritant ingredients to pre-establish protective barriers on the skin or mucous membrane surface. This preliminary action prevents subsequent irritation and inflammation while allowing the cosmetic composition to maintain its effectiveness
3Reliability
If the skin barrier is compromised to allow ingredient penetration, then the ingredient can reach target cells, but it increases vulnerability to irritants and inflammation
Solution Approach 1:
The patent applies hyperbranched dextrins as a cushioning protective layer before irritant ingredients can compromise the skin barrier. This prior cushioning prevents the skin barrier from being breached and avoids subsequent inflammation, maintaining both barrier integrity and vulnerability to harmful factors
Data Source
AI summary
Hyperbranched dextrins, preferentially hyperbranched and hydrogenated dextrins, for topical use in the prevention or treatment of at least one symptom selected from redness, heat, swelling and pain, as well as in the prevention or treatment of the symptoms of skin inflammation and of mucosal inflammation. The invention also relates to the use of these hyperbranched, and preferably hyperbranched and hydrogenated, dextrins to prevent or reduce or eliminate the irritant effect induced by ingredients contained in cosmetic or dermatological compositions.