Hypericum Extract in Neem Oil: Vacuum Agitation and Carbon Filtration
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Solution Overview
Problem
Existing methods for preparing Hypericum perforatum extracts in Neem oil face reproducibility issues due to variability in process conditions and result in turbidity at low temperatures, limiting their applicability and stability.
Innovation Solution
An industrial extraction method using Neem oil as the sole extracting solution, involving a vacuum-heated reactor with agitation and controlled irradiation, allowing for the selection of additional solvents to prevent precipitation and enhance stability across a wide temperature range.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If spagyric maceration is used for extraction, then the process is simple and traditional, but the results lack reproducibility due to variability in process conditions and the extract becomes turbid at low temperatures
Solution Approach 1:
The patent applies parameter changes by controlling temperature, time, lighting degree, agitation speed, and drugs-to-oil ratio within specific ranges to ensure reproducible extraction results. The process maintains temperature between 16-25°C, uses controlled agitation speeds, and specifies exact maceration times to eliminate variability inherent in traditional spagyric methods.
Solution Approach 2:
The patent introduces an intermediary step of filtering the extract through activated carbon to remove precipitating substances before final formulation. This intermediary purification step prevents turbidity formation at low temperatures while preserving the therapeutic properties of the hypericum extract.
2Ease of manufacture
If hypericum extract is prepared in Neem oil using traditional methods, then the preparation is economical, but it develops turbidity at 16°C due to precipitation of hydrocarbons and fat acids
Solution Approach 1:
The patent changes the physical-chemical parameters of the extraction process by controlling temperature (16-25°C), pH levels, and composition ratios to prevent precipitation. The extract is prepared at controlled temperatures and then stabilized through filtration and controlled cooling to maintain clarity at low temperatures without compromising economic feasibility.
Solution Approach 2:
The patent extracts and removes the precipitating substances (hydrocarbons and fat acids) through filtration with activated carbon before final product formulation. This selective removal of problematic components eliminates turbidity while preserving the active medicinal constituents.
3Device complexity
If traditional spagyric maceration is used, then the process requires minimal equipment, but it is subjected to climatic factor variability and requires variable process times
Solution Approach 1:
The patent introduces dynamic control elements to the extraction process, including controlled agitation at variable speeds, regulated temperature maintenance, and timed maceration cycles. These dynamic parameters are adjusted based on real-time monitoring to compensate for climatic variations and ensure consistent processing times regardless of environmental conditions.
Solution Approach 2:
The patent implements feedback control by monitoring temperature, agitation effectiveness, and extraction progress throughout the maceration process. Based on this feedback, the process parameters are adjusted to maintain optimal extraction conditions and achieve consistent results within predetermined time frames, eliminating the variability inherent in unmonitored traditional methods.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method achieves high yield and stability of bioactive Hypericum extracts in Neem oil, maintaining efficacy as an anti-inflammatory, antiseptic, and cicatrizing agent while extending its applicability range, including as a myasis repellent, with improved reproducibility and temperature resistance.
Implementation Method 1
The container is heated at vacuum state with pression not lower than 0.04 atmospheres
Implementation Method 2
equipped with central rotatory axis carrying, inserted on the axis, agitation blades, that can to be rotate with variable speed
Implementation Method 3
The container carries an airtight glass cover permeable to the radiations in the visible spectrum field
Data Source
AI summary
A method for making a Hypericum perforatum extract in Neem oil, provides of: combining an amount of Hypericum flowers and/or capsules with a quantity of Neem oil; - introducing into a reactor the mixture made of the amounts of Hypericum flowers and/or capsules and of Neem oil; maintaining the mixture vacuum, under agitation for a predefined time and temperature. A composition includes Neem oil and Hypericum flowers and/or capsules. Such composition includes moreover a solvent or a mixture of solvents.