Personalized Hyperimmune Egg Production for Psoriasis Treatment
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Solution Overview
Problem
Current treatments for psoriasis are ineffective against antibiotic-resistant pathogens and do not address the underlying autoimmune response, leading to chronic symptoms and impaired tissue resistance.
Innovation Solution
Development of personalized hyperimmune eggs (Ovopach) containing specific IgY antibodies produced in response to patient-specific pathogenic agents, which are used to immunize chickens, resulting in eggs with anti-anti-pathogenic complex antibodies that can be administered to patients to target and neutralize pathogenic germs.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional antibiotic treatments are used, then treatment simplicity is maintained, but treatment effectiveness deteriorates due to antibiotic-resistant pathogens
Solution Approach 1:
The patent uses chickens as intermediary organisms to produce IgY antibodies against pathogenic germs. The chicken immune system processes the pathogen antigens and produces specific antibodies that are then extracted from egg yolks. This intermediary approach allows the production of highly specific, effective treatments without requiring complex direct human immunization protocols or developing new antibiotics.
Solution Approach 2:
The patent creates a copy of the pathogenic germ's antigenic structure through the chicken immune response. The IgY antibodies are precise molecular copies that recognize and bind to specific epitopes on the pathogenic germs. This copying mechanism enables the treatment to specifically target the pathogen without affecting other organisms, providing high effectiveness while maintaining simplicity in administration.
2Reliability
If personalized immunization protocols are developed, then treatment specificity is improved, but production time and complexity increase
Solution Approach 1:
The patent employs preliminary action by using the chicken immune system to pre-produce the specific antibodies before they are needed for human treatment. The chickens are immunized with the patient's specific pathogenic germs in advance, allowing the immune system to generate high-affinity IgY antibodies that can be harvested from eggs. This preliminary production in chickens eliminates the need for time-consuming human immunization protocols while maintaining high specificity.
Solution Approach 2:
The patent uses short-living chicken organisms as disposable production platforms. Each chicken can be immunized with a specific patient's pathogens, produce the required IgY antibodies, and then the process can be repeated with new chickens for subsequent patients. This approach allows rapid production of personalized treatments without requiring long-term maintenance of immortalized cell lines or complex bioreactor systems.
3Manufacturing precision
If hyperimmune eggs are produced through chicken immunization, then antibody specificity is improved, but manufacturing complexity increases
Solution Approach 1:
The patent exploits the self-service capability of the chicken immune system to automatically produce highly specific antibodies. When chickens are immunized with pathogenic germs, their immune systems autonomously recognize the antigens, activate B cells, and produce IgY antibodies with high specificity. This self-service mechanism eliminates the need for complex mammalian cell culture systems, transfection protocols, or sophisticated bioreactor equipment, thereby reducing manufacturing complexity while maintaining high antibody specificity.
Solution Approach 2:
The patent uses the chicken egg as a multi-functional platform that serves both as the immunization vehicle and as the production factory for antibodies. The egg yolk naturally concentrates the IgY antibodies produced by the chicken, providing a simple extraction method. This universal use of the egg system eliminates the need for separate production and purification systems, reducing overall manufacturing complexity while achieving high antibody specificity through the chicken's natural immune response.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The Ovopach hyperimmune eggs provide a targeted and effective treatment by activating the immune system to recognize and combat specific pathogens, reducing symptoms and improving tissue resistance in psoriasis patients, even in cases resistant to conventional antibiotic treatments.
Implementation Method 1
The inactivated antigenic product mixed with adjuvant QS21 is used for the fast immunization of laying chickens
Implementation Method 2
The antigen obtained after cultivation of the pathological cell material sampled from the patient in culture medium for 24 or 48 hours at 37 °C, is inactivated in formalin or thermally or by gamma rays
Implementation Method 3
The antigen obtained after cultivation of the pathological cell material sampled from the patient in culture medium for 24 or 48 hours at 37 °C, is inactivated in formalin or thermally or by gamma rays
Implementation Method 4
The antigen obtained after cultivation of the pathological cell material sampled from the patient in culture medium for 24 or 48 hours at 37 °C, is inactivated in formalin or thermally or by gamma rays
Implementation Method 5
The Ovopach hyperimmune egg contains anti-anti-personalized pathogenic complex (AIAACPI) idiopathic antibodies which recognize the epitopes defined by the peptides in the personalized pathogenic product
Implementation Method 6
The extracted IgY is twenty times concentrated by tangential filtration
Implementation Method 7
The personalized IgY is sterilized by filtration through 0,45 μιη and 0,22 μιη Millipore filters
Implementation Method 8
The immune response of immunized chickens is daily monitored by highlighting IgY in egg yolk. The specific qualitative and quantitative . immune response against the administered antigen shall be monitored
Data Source
AI summary
This invention refers to the discovery of the way of treating psoriasis using personalized chicken immunoglobulin therapy. Chickens are immunized with an immunogen prepared from skin wound samples taken from each and every patient. This invention refers to the a particular immunogen, taken from the patient, mixed with an adjuvant and which, when administered in chickens, yields a specific immune response within an appropriate period of time so that the Ovopach eggs obtained from these chickens should be used under stringent conditions in the psoriasis treatment of the patient. The immunogen is polyspecific and contains microbial and cellular antigens found in the psoriasis wounds of the patient. The specific immune response from the immunized chickens is monitored on daily basis by extraction of immunoglobulins (Ig) from the egg yolk (Y) and qualitative and quantitative assessment by ELISA, radial immunodiffusion and Ouchterlony immunodiffusion assay. The immune response of chickens, expressed by the yolk-extracted antibodies, is a complex, multiple response against all antigenic stimuli present in the pathogenic product taken from the patient.