Stable Hypochlorite Formulations Using pH Buffers
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Solution Overview
Problem
There is a need for stable and effective cosmetic and medicinal formulations that incorporate reactive oxygen species, which are currently limited by instability and undesirable characteristics.
Innovation Solution
The compositions include a saline solution with Himalayan sea salt, hypochlorite as a reactive oxygen species, an emollient such as silicone polymer, and a pH modifying agent like sodium phosphate monobasic, optionally with a rheology agent like sodium magnesium silicate, to create stable formulations suitable for various applications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If reactive oxygen species are incorporated into cosmetic and medicinal formulations, then antimicrobial and therapeutic effects are improved, but formulation stability deteriorates
Solution Approach 1:
The patent stabilizes reactive oxygen species (hypochlorite) by controlling formulation parameters including pH (maintained between 5-8 using buffers), ionic strength (adjusted with salts like sodium chloride), and temperature. These parameter changes prevent premature decomposition of the reactive oxygen species while maintaining antimicrobial effectiveness.
Solution Approach 2:
The patent introduces buffer systems (such as phosphate buffers, citrate buffers, or bicarbonate buffers) as intermediary substances that mediate between the reactive oxygen species and the formulation environment. These buffers stabilize the pH and protect the hypochlorite from degradation, allowing the active ingredient to remain effective without compromising formulation stability.
2Reliability
If saline solution with high salt concentration is used, then microbial inhibition is improved, but skin compatibility and comfort deteriorate
Solution Approach 1:
The patent optimizes the salt concentration parameter to balance microbial inhibition and skin compatibility. By maintaining salt concentration at physiological levels (0.9% sodium chloride) rather than high concentrations, the formulation achieves adequate microbial protection without causing skin irritation or discomfort.
Solution Approach 2:
The patent creates different local environments within the formulation: the saline component provides antimicrobial protection at controlled concentrations, while emollients and pH buffers create a skin-friendly local environment. This local quality differentiation allows the formulation to simultaneously achieve microbial inhibition and skin compatibility.
3Object-affected harmful factors
If emollients are added to improve skin comfort, then skin compatibility is improved, but formulation stability of reactive oxygen species deteriorates
Solution Approach 1:
The patent introduces pH buffers and chelating agents as intermediary substances that protect reactive oxygen species from degradation by emollients and other formulation components. These intermediaries maintain the chemical environment necessary for hypochlorite stability while allowing emollients to provide skin comfort benefits.
Solution Approach 2:
The patent creates a composite formulation system where incompatible components (emollients and reactive oxygen species) are combined through careful selection of compatible excipients and controlled formulation conditions. The composite structure allows emollients to provide skin comfort while the buffer system and pH control maintain reactive oxygen species stability.
4Reliability
If pH modifying agents are used to optimize effectiveness, then therapeutic performance is improved, but formulation complexity increases
Solution Approach 1:
The patent selects pH modifying agents that perform multiple functions: buffering capacity to stabilize pH, skin compatibility to maintain comfort, and compatibility with other formulation components. This multi-functionality reduces the need for additional separate ingredients, thereby managing formulation complexity while optimizing therapeutic performance.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compositions provide stable and effective formulations that maintain desirable characteristics, enhancing skin health and stability, improving appearance, and extending shelf life.
Implementation Method 1
a pH modifying agent like sodium phosphate monobasic
Data Source
AI summary
Described herein are compositions that include a saline solution and reactive oxygen species. Specifically, the composition may include a saline solution, reactive oxygen species, an emollient, and a pH modifier. Also provided is a gel composition that includes a rheology agent. Also provided are methods of making and using the compositions.