Stabilized Hypochlorous Acid Solution for Abdominal Surgery Infection Prevention
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Solution Overview
Problem
During abdominal surgery, bacterial translocation from the intestine can lead to complications such as sepsis, bacteraemia, and endotoxaemia due to increased intestinal permeability, resulting in prolonged hospital stays and increased morbidity and mortality.
Innovation Solution
An antimicrobial solution comprising hypochlorous acid, a divalent cation (such as magnesium), phosphate anion, and water, which is prepared by adding chlorine gas to a mixture containing these components, is administered to prevent or treat infections by reducing bacterial translocation and maintaining stability for extended periods.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If hypochlorous acid solution is used to prevent bacterial translocation during abdominal surgery, then antimicrobial effectiveness is improved, but solution stability deteriorates due to decomposition over time
Solution Approach 1:
The patent adjusts key parameters including pH (maintained at 3.0-7.0 through buffer systems), hypochlorous acid concentration (10-500 mg/L), and ionic composition (divalent cations at 10-250 mg/L, phosphate anions at 200-1000 mg/L) to optimize both stability and antimicrobial effectiveness. These parameter changes create a balanced formulation that resists decomposition while maintaining therapeutic activity
Solution Approach 2:
The solution employs a composite formulation combining hypochlorous acid with buffer systems (phosphate anions), ionic components (divalent cations such as magnesium or calcium), and pH-adjusting agents. This composite structure provides mutual support: buffers maintain pH stability, ions enhance antimicrobial activity, and the combination prevents rapid decomposition, achieving both stability and effectiveness simultaneously
2Speed
If conventional antimicrobial solutions are used, then immediate antimicrobial action is achieved, but prolonged stability and maintained concentration are lost
Solution Approach 1:
The solution maintains continuous antimicrobial activity through sustained release mechanisms. The buffer systems and ionic components prevent rapid degradation, ensuring that hypochlorous acid remains active at therapeutic concentrations over extended periods. This continuity allows the solution to provide both immediate action upon application and prolonged protection during hospital stays
Solution Approach 2:
The formulation contains self-regulating components including buffer systems that automatically maintain pH within the optimal range (3.0-7.0) and ionic components that enhance stability. These components work autonomously to prevent decomposition and maintain antimicrobial activity without requiring external intervention, ensuring both immediate effectiveness and prolonged stability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The antimicrobial solution effectively reduces microbial loads by at least four to seven logs, providing a stable and effective treatment for preventing infections associated with abdominal surgery, with prolonged stability and maintained concentrations of active ingredients.
Implementation Method 1
adding chlorine gas to the mixture
Data Source
AI summary
Disclosed is an antimicrobial solution comprising, consisting essentially of, or consisting of (a) hypochlorous acid, (b) a divalent cation, (c) phosphate anion, and (d) water, as well as a process for its production. Also disclosed is a method of treating or preventing infection associated with abdominal surgery on a mammal, comprising use of the antimicrobial solution.