Hypotonic Fat Decomposition Composition
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Solution Overview
Problem
The use of sodium deoxycholate alone for fat decomposition in lipoplasty procedures often results in adverse effects such as edema, erythema, pain, and callosity due to its impact on fat cells and surrounding tissues, including nerve, muscle, and bone cells.
Innovation Solution
A hypotonic composition containing sodium deoxycholate, hyaluronidase, and optional buffer and additive in a hypotonic solution of distilled water and sodium chloride is developed, which selectively disrupts fat cells through osmotic pressure differences and enhances drug delivery to reduce fat volume while minimizing adverse effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If sodium deoxycholate alone is used for fat decomposition, then fat cell disruption is achieved, but adverse effects such as edema, erythema, pain, and callosity occur
Solution Approach 1:
The patent changes the tonicity parameter of the solution from isotonic to hypotonic, creating an osmotic pressure difference that selectively disrupts fat cells while sparing surrounding tissues. This parameter change enables fat decomposition effectiveness while reducing adverse effects on nerves, muscles, and bones.
Solution Approach 2:
The patent creates a composite injection composition combining sodium deoxycholate with hyaluronidase in a hypotonic solution. This composite formulation enhances the fat decomposition effect while the hypotonic environment protects surrounding tissues from damage, resolving the contradiction between effectiveness and safety.
2Reliability
If complex preparation injection using phosphatidylcholine and sodium deoxycholate is used, then lipoplasty effect is achieved, but fat necrosis occurs
Solution Approach 1:
The patent extracts and removes phosphatidylcholine from the complex preparation, using sodium deoxycholate alone in a hypotonic solution. This extraction eliminates the fat necrosis problem associated with phosphatidylcholine while maintaining the lipoplasty effectiveness through the hypotonic mechanism.
Solution Approach 2:
The patent converts the potentially harmful high concentration of sodium deoxycholate into a beneficial treatment by dissolving it in a hypotonic solution. The hypotonic environment creates selective pressure that benefits fat cell disruption while preventing the harmful effects of concentrated sodium deoxycholate on surrounding tissues.
3Productivity
If high dose of sodium deoxycholate is used for efficient fat decomposition, then fat volume reduction is improved, but adverse effects increase
Solution Approach 1:
The patent changes the tonicity parameter to hypotonic, which enables efficient fat decomposition at lower sodium deoxycholate concentrations. The osmotic pressure difference created by the hypotonic solution enhances fat cell disruption efficiency while reducing the need for high doses, thereby minimizing adverse effects.
Solution Approach 2:
The hypotonic solution acts as an intermediary medium that enhances the effectiveness of low-dose sodium deoxycholate. This intermediary creates an osmotic environment that facilitates fat cell disruption, allowing efficient decomposition without requiring high concentrations that would cause edema, erythema, and pain.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces fat volume with reduced adverse effects like edema, erythema, and pain, and allows for efficient fat decomposition using a low dose of sodium deoxycholate, making it suitable for topical fat reduction through subcutaneous administration.
Implementation Method 1
a balance being a hypotonic solution for inducing physical decomposition of fat cells by an osmotic pressure difference
Implementation Method 2
sodium deoxycholate for selectively disrupting fat cells to reduce the volume of fat
Implementation Method 3
the hyaluronidase increasing the permeability of a drug into subcutaneous connective tissue
Data Source
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AI summary
Disclosed are a hypotonic composition for fat decomposition and a method for preparing the same. That is, according to the present invention, a hypotonic composition for fat decomposition is prepared to contain sodium deoxycholate, hyaluronidase, and the like in a hypotonic solution composed of distilled water and sodium hydrochloride.