Nutritional Composition for IBD Musculoskeletal Health
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Solution Overview
Problem
Patients with inflammatory bowel disease, such as Crohn's disease, face challenges in managing metabolic changes, bone health, and predicting relapses, with existing nutritional compositions often failing to effectively promote musculoskeletal health and restore metabolic profiles.
Innovation Solution
A nutritional composition comprising acid casein protein, a vitamin K1:K2 ratio between 3:1 to 1:3, vitamin D in amounts of 2.5 to 75 μg/100 g, and n6/n3 fatty acids in a ratio of 5:1 to 1:5, which is administered to pediatric patients to improve musculoskeletal health and induce remission, promoting gut mucosal healing and bone density.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional nutritional compositions are used for IBD patients, then basic nutritional needs are met, but musculoskeletal health is not effectively promoted and bone density is not improved
Solution Approach 1:
The patent applies parameter changes by modifying the vitamin K composition from conventional single-form vitamin K to a specific combination of vitamin K1 and K2 in a ratio of 1:4 to 4:1. This parameter change in the nutritional composition enables improved bone density and musculoskeletal health outcomes in IBD patients, addressing the inadequacy of conventional compositions.
Solution Approach 2:
The patent employs composite materials by combining multiple forms of vitamin K (K1 and K2) with casein protein and specific fatty acid ratios (n-6:n-3 of 1:4 to 4:1) to create a composite nutritional composition. This composite approach synergistically promotes bone density, muscle mass, and overall musculoskeletal health beyond what single-nutrient compositions achieve.
2Reliability
If nutritional compositions with high vitamin K content are administered, then bone density improves, but the specific ratio of vitamin K1:K2 is not optimized for maximum musculoskeletal benefit
Solution Approach 1:
The patent precisely controls the vitamin K1:K2 ratio parameter within 1:4 to 4:1 to optimize bone density and musculoskeletal outcomes. This parameter optimization ensures maximum therapeutic effect while avoiding the inadequacies of conventional compositions that do not specify this critical ratio.
3Productivity
If standard fatty acid compositions are used in nutritional formulas, then basic caloric needs are met, but the n-6:n-3 ratio does not optimize anti-inflammatory effects and remission outcomes
Solution Approach 1:
The patent modifies the fatty acid composition parameter by establishing an n-6:n-3 ratio of 1:4 to 4:1, which optimizes anti-inflammatory effects and enhances remission induction in IBD patients. This parameter change transforms the nutritional composition from merely providing calories to actively promoting therapeutic outcomes.
Data Source
AI summary
A nutritional composition promotes musculoskeletal health in patients with inflammatory bowel disease. The nutritional composition contains casein protein, vitamin D, alpha-linolenic acid, and vitamin K in a ratio of vitamin K1:vitamin K2 between 3:1 to 1:3 and the vitamin K providing between 3.5-20 μg/100 cal of the nutritional composition. A pharmaceutical formulation, a nutritional formulation, a tube-feed formulation, a dietary supplement, a functional food, a beverage product or a combination thereof comprising the nutritional composition is also disclosed. A method for improving musculoskeletal health is also disclosed.