Ibuprofen Transdermal Patch Matrix to Prevent Recrystallization

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Solution Overview

Problem

Existing transdermal drug delivery systems for ibuprofen face challenges in achieving high drug loading without recrystallization, maintaining stable drug concentration, and ensuring adhesion and cohesion during prolonged use, particularly due to ibuprofen's interactions with polymer matrices and skin.

Innovation Solution

A multi-layer transdermal drug delivery system with a polymer matrix containing ibuprofen or its structural analogue, where ibuprofen forms a salt with an amino compound, maintaining uniform dispersion and preventing recrystallization, while using a combination of acrylic and polysilicone pressure-sensitive adhesives and fillers to ensure adhesion and cohesion.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If ibuprofen is highly loaded in the polymer matrix to achieve therapeutic dose delivery, then the drug loading amount is improved, but recrystallization occurs during storage which affects stability

Engineering Contradiction:

Improveibuprofen loading amountVSAvoiddrug stability

Core Design Contradiction:

Quantity of substanceVSStability of the object's composition

Solution Approach 1:

An amino compound is introduced as an intermediary substance between ibuprofen and the polymer matrix. The amino compound forms a salt with ibuprofen, creating a stable complex that prevents recrystallization while maintaining high drug loading levels in the transdermal patch.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Duration of action of moving object

If the patch is designed for long-term wear (12-24 hours) to reduce administration frequency, then the duration of action is improved, but adhesion stability and wearability become compromised

Engineering Contradiction:

Improvepatch wear durationVSAvoidadhesion stability

Core Design Contradiction:

Duration of action of moving objectVSReliability

Solution Approach 1:

The patch employs a composite polymer matrix structure combining multiple polymer components with distinct functions. This composite material system provides both long-term adhesion stability for extended wear and controlled drug release properties, maintaining reliability over 12-24 hour periods.

Inventive Principle:

Principle #40Composite materials

3Productivity

If ibuprofen is dissolved in the polymer matrix to enable transdermal delivery, then the drug can be delivered systemically, but the drug may interact with polymer components reducing delivery efficiency

Engineering Contradiction:

Improvetransdermal delivery efficiencyVSAvoiddrug-polymer interaction stability

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The amino compound serves as a mediator that complexes with ibuprofen, reducing direct interactions between the drug and polymer matrix components. This intermediary complex maintains drug stability while enabling efficient transdermal delivery through the skin.

Inventive Principle:

Principle #24Intermediary (Mediator)

4Ease of operation

If gel creams are used as surface preparations for ibuprofen delivery, then the drug can be applied topically, but special operations are required and local drug loss occurs during use

Engineering Contradiction:

Improveapplication convenienceVSAvoidlocal drug loss

Core Design Contradiction:

Ease of operationVSLoss of substance

Solution Approach 1:

The invention uses a flexible transdermal patch in the form of a thin film that adheres to the skin surface. This film structure eliminates the need for special application operations required by gel creams and prevents local drug loss through controlled release, while still enabling topical delivery.

Inventive Principle:

Principle #30Flexible shells and thin films

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system achieves continuous and stable drug delivery for 12 to 24 hours with high transdermal penetration efficiency, preventing recrystallization and ensuring good adhesive properties, reducing cobwebbing and residues on the skin.

Implementation Method 1

ibuprofen forms a salt with an amino compound

Methodology Applied

Scientific EffectSalt formation: Chemical Bonding

Implementation Method 2

Transdermal drug delivery is an ideal means to meet the requirements of ibuprofen administration

Methodology Applied

Scientific EffectDiffusion: Diffusion

Data Source

PatentUS12629343B2Multi-layer transdermal drug delivery system containing ibuprofen or structural analogue thereof

Publication Date: 2026.05.19 DEMOTECH INC

AI summary

A multi-layer transdermal drug delivery system containing ibuprofen or a structural analogue thereof, comprising a transdermal patch containing ibuprofen or a structural analogue thereof and a second combined layer. The transdermal patch comprises a polymer matrix layer, the polymer matrix layer comprising an active ingredient, a compound containing at least one amino group, and a pressure-sensitive adhesive. All or some of active ingredient-amino compound salts or all or some of free active ingredients formed in the polymer matrix layer are kept in a uniform dissolution state in the polymer matrix, and can be stably stored before use, without recrystallization. The transdermal drug delivery system can continuously and controllably deliver a therapeutically effective amount of ibuprofen or a structural analogue thereof for 12 to 24 hours in the absence of a transdermal enhancer, has excellent wearing ability, and avoids a cold flow phenomenon.