Multi-Layered Ice Pop Medicament Delivery System
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Solution Overview
Problem
Conventional sublingual pharmaceutical delivery systems face challenges in regulating the release of multiple components in a time-release fashion, particularly for patients with oral conditions like oral mucositis, due to unpredictable dissolution and saliva production variability.
Innovation Solution
A multi-layered pharmaceutical delivery system comprising ingestible layers with specific delivery parameters, where each layer contains a pharmaceutical agent and transitions from a solid to a non-solid phase upon ingestion, allowing controlled sequential delivery of medicaments, including sublingual, buccal, or urogenital administration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional sublingual delivery systems use dissolvable solid pills or strips, then medication can be delivered through the mucous membrane, but the dissolution is unpredictable and cannot regulate delivery of multiple components in a time release fashion
Solution Approach 1:
The pharmaceutical composition is divided into multiple discrete layers, each containing different pharmaceutical agents. Each layer dissolves at a different rate to provide controlled sequential delivery of multiple medications, transforming the undifferentiated dissolution problem into a structured multi-layer system with predictable delivery timing.
Solution Approach 2:
Multiple pharmaceutical layers are nested within each other in a concentric arrangement, with each layer containing specific agents that dissolve at different rates. This nested structure allows sequential exposure of different medication layers to saliva, enabling time-release delivery without requiring complex mechanical mechanisms.
2Duration of action of moving object
If aerosol sprays are used for sublingual delivery, then medication can be administered, but they cannot be administered in a time delayed or extended fashion
Solution Approach 1:
The multi-layer pharmaceutical composition provides continuous medication delivery as each layer dissolves sequentially in the patient's saliva. This eliminates the need for repeated spraying actions, as the layered structure ensures continuous release of different pharmaceutical agents over an extended period without requiring patient intervention.
3Reliability
If solid pharmaceutical forms are used for sublingual delivery, then medication can be delivered, but dissolution via exposure to saliva is especially unpredictable
Solution Approach 1:
Each layer of the pharmaceutical composition is designed with distinct local properties, including different compositions, thicknesses, and dissolution rates tailored to specific pharmaceutical agents. This allows each layer to dissolve at a predictable rate independent of variations in overall saliva production, providing reliable sequential delivery adapted to different patient conditions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system ensures controlled and sequential delivery of pharmaceutical agents, enhancing patient tolerance and efficacy, especially for conditions like oral mucositis, by adjusting the melting or sublimation points of the layers to manage pain and inflammation.
Implementation Method 1
Each layer may be configured to transition from a solid to a non-solid following ingestion. The transition may comprise melting from a solid phase to a liquid phase.
Implementation Method 2
Such transition may comprise sublimation from a solid phase to a gas phase.
Data Source
AI summary
A multi-layered pharmaceutical delivery system is contemplated in which the delivery of medicaments to patients is controlled via the sequential delivery of medicaments contained within ingestible solid pharmaceutical layers, preferably frozen in a media that liquefies following ingestion by a patient so as to release the medicament when ingested by melting. A frozen ice pop embodiment is contemplated to contain an outermost ingestible pharmaceutical layer enclosing further ingestible pharmaceutical layers sequentially enclosed within that inner pharmaceutical layer. Other embodiments are contemplated in which the layers are linearly sequenced within an external container that prevents ingestion of the subsequent layers until the prior layers have been ingested.