Multi-Point ICG Fluorescence Monitoring for Accurate Cardiac Flow
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Solution Overview
Problem
Current methods for estimating cardiac output, such as blood pressure and invasive catheter techniques, are inaccurate and prone to complications, while existing ultrasound and fluorescence-based methods are influenced by environmental factors and operator proficiency.
Innovation Solution
A system and method for time-series analysis of fluorescent blood flow using Indocyanine Green (ICG) fluorescence, employing movable monitoring devices at multiple body points with darkroom spaces to capture and process fluorescent contrast agent signals, reducing interference and enhancing accuracy through multi-point detection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If percutaneous detection of ICG fluorescence intensity is used for estimating cardiac output, then the method is non-invasive and feasible, but it is susceptible to environmental light interference and distance variations
Solution Approach 1:
The system divides the detection process into multiple time-series detection points, capturing fluorescence intensity at different moments. This temporal segmentation allows the system to distinguish the fluorescent signal from environmental noise by analyzing signal characteristics across multiple time points, thereby improving measurement precision while maintaining non-invasive operation.
Solution Approach 2:
The patent implements a darkroom space that isolates the detection area from environmental light interference. By creating an optically controlled environment that blocks external light sources, the system eliminates the harmful effect of environmental light on fluorescence detection, enabling accurate non-invasive measurements without susceptibility to ambient lighting conditions.
2Measurement precision
If multiple time-series detection points are used, then the signal-to-noise ratio is improved and accuracy is enhanced, but the device complexity increases
Solution Approach 1:
The monitoring device is designed as an integrated multi-functional system that combines light sources, filters, detectors, and processing capabilities in a single unit. This universal design allows the device to perform multiple detection functions at different time points without requiring separate complex equipment for each measurement, thereby enhancing signal-to-noise ratio through multi-point detection while controlling overall device complexity.
3Measurement precision
If invasive catheter placement is used for accurate hemodynamic monitoring, then cardiac output measurement accuracy is improved, but vascular complications and insertion risks increase
Solution Approach 1:
The system replaces invasive mechanical catheter insertion with non-invasive optical detection. By using fluorescence imaging technology to track ICG tracer distribution and calculate cardiac output through image analysis, the system achieves accurate hemodynamic monitoring without requiring physical catheter placement in blood vessels, thereby eliminating vascular insertion complications while maintaining measurement precision.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Improves cardiac output estimation by minimizing environmental interference and operator dependence, providing accurate and non-invasive monitoring of blood flow velocity and dynamic information, with enhanced signal-to-noise ratio.
Implementation Method 1
The detection device further comprises at least two near-infrared led light sources and a filter receiver
Implementation Method 2
capture a fluorescent contrast agent signal in human blood
Implementation Method 3
a filter receiver, wherein the filter receiver is obtained a fluorescent contrast agent signal by reflecting light onto the skin
Data Source
AI summary
A system for time-series analysis of fluorescence blood flow includes at least two mobile fluorescent blood flow monitoring devices disposed on the human limbs and processing devices. The movable fluorescent blood flow monitoring device includes the body, a fixed device, a darkroom space, a detection device, a transmission device, and a battery unit. The detection device further comprises at least four LED excitation light sources with a wavelength of 740 nm to 760 nm and a filter receiver. The filter receiver receives reflected fluorescence light with a wavelength of 800 nm to 850 nm to obtain a fluorescent developer signals from human blood perfused tissue, and the cardiac blood flow rate result is calculated by the processing device. A monitoring method is to calculate the cardiac blood flow rate result by the fluorescent developer signal captured by the first and second movable fluorescence blood flow monitoring devices.