Simultaneous Elemental Detection in ICP-MS Using Continuous Flow Calibration
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Solution Overview
Problem
Current methods for measuring elemental concentrations from 6Li to 238U using inductively coupled plasma mass spectrometry (ICP-MS) are limited by sequential analysis, requiring high sample volumes and significant time and resources, making it impractical to evaluate the entire relevant inorganic spectrum, and lack a comprehensive calibration method for simultaneous measurement.
Innovation Solution
A calibration method using an internal standard composition and a kit with calibration standards that allow for the simultaneous detection of multiple elements over a wide mass range, including a combination of three elements from different periodic table periods, and a plurality of calibration standards covering concentrations from 6Li to 238U, enabling the simultaneous measurement of 71 elements in aqueous samples.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If sequential ICP-MS analysis is used to detect elements, then measurement precision is maintained, but analysis time and sample volume requirements increase significantly
Solution Approach 1:
The patent combines multiple sequential measurements into a single simultaneous measurement event by using a continuous flow analysis system where the sample flows continuously through the ICP-MS instrument, allowing multiple elements to be detected at the same time while maintaining the measurement precision of sequential analysis
Solution Approach 2:
The patent implements preliminary action by continuously flowing the sample through the system before analysis, ensuring that the sample is continuously available and properly prepared in the flow cell, which enables simultaneous detection without requiring multiple separate sample introductions
2Measurement precision
If sequential ICP-MS analysis is used to detect elements, then measurement accuracy is maintained, but sample volume consumption increases
Solution Approach 1:
The patent merges multiple sequential sample measurements into a single continuous sample flow that serves all detection channels simultaneously, thereby dramatically reducing the total sample volume required while maintaining measurement precision through continuous monitoring
Solution Approach 2:
The patent employs continuous flow analysis where the sample continuously flows through the ICP-MS instrument, allowing uninterrupted simultaneous detection of multiple elements from a single sample introduction, thus minimizing sample volume consumption while maintaining accuracy
3Adaptability or versatility
If comprehensive elemental analysis from 6Li to 238U is performed using sequential methods, then complete spectral coverage is achieved, but operational complexity and resource requirements increase
Solution Approach 1:
The patent implements a universal detection system where a single continuous flow analysis configuration simultaneously detects all elements from 6Li to 238U across the entire mass spectrum, eliminating the need for multiple specialized measurement protocols and reducing operational complexity while maintaining comprehensive elemental coverage
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the simultaneous measurement of 71 elements from 6Li to 238U in aqueous samples, including water, beverages, and biological samples, with improved efficiency and accuracy, addressing the limitations of sequential analysis and providing a comprehensive method for elemental analysis.
Implementation Method 1
an inductively coupled plasma mass spectrometer capable of simultaneous detection of a large number of ionization products over a large range of masses
Implementation Method 2
inductively coupled plasma mass spectrometry
Data Source
AI summary
Disclosed herein are internal standard compositions, a plurality of calibration standards, and one or more kits for use with mass spectrometry, particularly for use with an inductively coupled plasma mass spectrometer capable of simultaneous detection of a large number of ionization products over a large range of masses. Methods of using these reagent materials for the simultaneously detection of absolute concentrations of a plurality of elements in a liquid sample.