ido-BR1 Extraction from Cucumis for Anti-Inflammatory Use
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Solution Overview
Problem
The active components responsible for the anti-inflammatory properties of cucumbers have not been identified, limiting the understanding and utilization of their medicinal benefits.
Innovation Solution
A process for producing (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid, also known as ido-BR1, from plants of the genus Cucumis, involving extraction and formulation with cosmetically, nutraceutically, or pharmaceutically acceptable excipients to create cosmetic, nutraceutical, or pharmaceutical compositions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cucumber extracts are used for anti-inflammatory treatment, then anti-inflammatory effect is achieved, but the active component remains unidentified
Solution Approach 1:
The patent extracts the active component ido-BR1 from cucumber plant material through systematic isolation and identification processes. This resolves the contradiction by separating the unknown active principle from the crude extract, thereby identifying it while preserving its anti-inflammatory therapeutic effect.
2Productivity
If modern commercial cucumber varieties are used, then availability is improved, but ido-BR1 content is reduced or absent
Solution Approach 1:
The patent identifies that ido-BR1 content varies by cucumber variety, cultivar, and ripeness stage. By optimizing these parameters - selecting appropriate varieties, cultivars, and harvest timing - the patent maximizes ido-BR1 content while maintaining the practical availability of cucumber as a source material.
3Manufacturing precision
If synthesis of ido-BR1 is performed, then pure compound is obtained, but complex multi-step process is required
Solution Approach 1:
Instead of performing complex chemical synthesis to create ido-BR1, the patent extracts and isolates the naturally occurring compound directly from cucumber plant material. This copying approach obtains pure ido-BR1 through extraction and purification rather than synthesis, significantly reducing process complexity while maintaining high purity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process effectively identifies and harnesses ido-BR1 as a key bioactive principle for anti-inflammatory herbal medicines, enabling the production of compositions that can treat inflammatory diseases.
Implementation Method 1
extracting (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid from said plant material
Data Source
AI summary
Composition comprising isolated ido-BR1 are described for use in therapy or prophylaxis, including the treatment of inflammatory diseases. (for example as anti-inflammatory drugs) and to reduce inflammation. Also described are methods for monitoring the quality of a Cucurbitaceae extract, to processes for producing a Cucurbitaceae extract as well as to Cucurbitaceae extracts obtainable by such processes.