IDO Inhibitor Compounds Modulating Tryptophan Metabolism
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Solution Overview
Problem
Current IDO inhibitors have limitations in efficacy for treating proliferative disorders such as cancer, viral infections, and autoimmune diseases, necessitating the development of new IDO modulators and compositions.
Innovation Solution
Development of compounds of formula (I) and their pharmaceutical compositions that can modulate or inhibit indoleamine 2,3-dioxygenase (IDO) activity, including pharmaceutically acceptable salts, stereoisomers, and solvates, for use in treating cancer and other IDO-related diseases.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current IDO inhibitors are used to treat proliferative disorders, then some therapeutic effect is achieved, but efficacy is limited
Solution Approach 1:
The patent applies parameter changes by modifying the chemical structure of IDO inhibitors through various substituents (R1-R6, A, Q, X) to optimize therapeutic efficacy. The systematic variation of molecular parameters (chemical groups, positions, configurations) enables improved inhibition potency and broader applicability across different proliferative disorders while maintaining selective IDO inhibition.
2Reliability
If new IDO modulators are developed to improve efficacy, then therapeutic benefits are enhanced, but compound complexity increases
Solution Approach 1:
The patent applies segmentation by dividing the IDO inhibitor molecule into distinct functional segments (core structure with defined A, Q, X, R1-R6 positions). Each segment can be independently optimized and combined, allowing systematic development of effective inhibitors while managing molecular complexity through modular design principles.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compounds effectively modulate IDO activity, providing therapeutic benefits in treating cancer, viral infections, and autoimmune diseases by altering tryptophan metabolism and immunosuppression, offering improved efficacy over existing inhibitors.
Implementation Method 1
The compounds effectively modulate IDO activity, providing therapeutic benefits in treating cancer, viral infections, and autoimmune diseases by altering tryptophan metabolism and immunosuppression
Data Source
AI summary
The present invention provides compounds of formula (I) wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.